CHina Adrenal Venous saMPling InvestigatiON
CHAMPION
China Adrenal Venous Sampling Investigation: A National Multicenter Study
1 other identifier
observational
5,000
1 country
76
Brief Summary
Primary aldosteronism (PA) is a major cause of secondary hypertension, yet its optimal diagnosis and management remain challenging. This study comprehensively evaluates adrenal venous sampling (AVS), addressing key clinical, technical, and methodological issues, and aims to clarify the relationship between AVS-guided management and long-term clinical and biochemical outcomes to optimize patient care and prognosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2025
Longer than P75 for all trials
76 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2025
CompletedFirst Submitted
Initial submission to the registry
November 19, 2025
CompletedFirst Posted
Study publicly available on registry
November 26, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 31, 2029
November 26, 2025
November 1, 2025
4.3 years
November 19, 2025
November 19, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Major adverse cardiovascular events (MACE) at 1-year follow-up
Incidence of major adverse cardiovascular events (MACE) at 1-year follow-up, including stroke, heart failure, severe arrhythmias, renal failure, myocardial infarction, and death.
1 year after AVS procedure
Secondary Outcomes (20)
The success rate of left adrenal venous sampling
At AVS procedure
The success rate of right adrenal venous sampling
At AVS procedure
The success rate of bilateral adrenal venous sampling
At AVS procedure
Selection of intraoperative catheter
At AVS procedure
Time of the procedure
At AVS procedure
- +15 more secondary outcomes
Study Arms (1)
Adrenal Venous Sampling
Patients with Primary Aldosteronism (PA) undergoing Adrenal Venous Sampling via antecubital approach or femoral approach to discriminate PA forms with unilateral from bilateral excess aldosterone production.
Interventions
Patients with Primary Aldosteronism (PA) undergoing Adrenal Venous Sampling via antecubital approach or femoral approach to discriminate PA forms with unilateral from bilateral excess aldosterone production.
Eligibility Criteria
All patients with confirmed primary aldosteronism underwent adrenal venous sampling.
You may qualify if:
- Patients with confirmed primary aldosteronism;
- Patients undergoing adrenal venous sampling for subtype classification of primary aldosteronism.
You may not qualify if:
- Severe comorbidity, including stroke, myocardial infarction, heart failure, severe valvular heart disease, liver cirrhosis, and metastatic tumor within the previous 3 months；
- An estimated glomerular filtration rate \<45 ml/min/1.73 m2, or serum creatinine \>176 μmol/L；
- Patients who refuse adrenalectomy;
- Suspected of having an adrenocortical carcinoma;
- Allergy to contrast agent;
- Pregnant, nursing, or planning to become pregnant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (76)
The first affiliated hospital of USTC
Hefei, Anhui, 230036, China
Chuiyangliu Hospital affiliated to Tsinghua University
Beijing, Beijing Municipality, 100022, China
China-Japan Friendship Hospital
Beijing, Beijing Municipality, 100029, China
Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, 100037, China
Peking University People's Hospital
Beijing, Beijing Municipality, 100044, China
Beijing Luhe Hospital, Capital Medical University
Beijing, Beijing Municipality, 101100, China
Chongqing University Central Hospital
Chongqing, Chongqing Municipality, 400000, China
Chongqing General Hospital
Chongqing, Chongqing Municipality, 401147, China
People's Hospital Affiliated to ChongqingThree Gorges Medical college
Chongqing, Chongqing Municipality, 404100, China
First Affiliated Hospital, Fujian Medical University, Fuzhou, China,
Fuzhou, Fujian, 0591-87982222, China
Cardiovascular Hospital Xiamen University
Xiamen, Fujian, 361016, China
Lanzhou University Second Hospital
Lanzhou, Gansu, 730000, China
The Forth People's Hosptal of Nanhai District of Foshan City
Foshan, Guangdong, 528211, China
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)
Guangzhou, Guangdong, 510080, China
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, Guangdong, 518000, China
Shenzhen Third People's Hospital，Shenzhen, Guangdong Province 518112, China
Shenzhen, Guangdong, 518112, China
Shenzhen Dapeng New District Kuiyong People's Hospital
Shenzhen, Guangdong, 518116, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, 530000, China
The Second Affliated Hospital Of GuangXi Medical Univesity
Nanning, Guangxi, 530007, China
Nanning Third People's Hospital
Nanning, Guangxi, 547000, China
Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China.
Guiyang, Guizhou, 550002, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, 550004, China
The Second Affiliated Hospital Of Guizhou Medical University
Kaili, Guizhou, 556000, China
Hainan General Hospital, Department of Endocrinology
Haikou, Hainan, 570311, China
Hainan General Hospital, Department of Cardiology
Hainan, Hainan, 570311, China
Tangshan hongci Hospital
Tangshan, Hebei, 063000, China
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001, China
The Second Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150086, China
Kai Feng the Peoples Hospital
Kaifeng, Henan, 475002, China
Fuwai Central China Cardiovascular Hospital
Zhengzhou, Henan, 450000, China
Henan Provincial People's Hospital
Zhengzhou, Henan, 450003, China
Zhengzhou Central Hospital Affiliated to Zhengzhou University
Zhengzhou, Henan, 450007, China
Zhengzhou Yihe Hospital
Zhengzhou, Henan, 450018, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
Zhoukou Central Hospital
Zhoukou, Henan, 466000, China
Renmin Hospital of Wuhan University
Wuhan, Hubei, 430060, China
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science
Xiangyang, Hubei, 441021, China
Yichang Central People's Hospital
Yichang, Hubei, 43000, China
Zhuzhou Hospital Affiliated to Xiangya School of Medicine,Central South University
Zhuzhou, Hunan, 412000, China
Xuzhou Central Hospital, Jiangsu
Xuzhou, Jiangsu, 221009, China
The First Affiliated Hospital of Gannan Medical University
Ganzhou, Jiangxi, 341000, China
Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)
Nanchang, Jiangxi, 330038, China
The First Hospital of Jilin University
Changchun, Jilin, 130021, China
Jilin Province FAW General Hospital
Changchun, Jilin, 130051, China
Affilated Zhongshan Hospital of Dalian University
Dalian, Liaoning, 116001, China
Frist Aiffiliated Hospital of Dalian Medical University
Dalian, Liaoning, 116011, China
The second hospital of Dalian Medical University
Dalian, Liaoning, 116027, China
Inner Mongolia Xing'an League People's Hospital
Ulanhot, Neimenggu, 137400, China
The First People's Hospital of Yinchuan
Yinchuan, Ningxia, 750000, China
Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital
Xining, Qinghai, 810000, China
Qinghai University Affiliated Hospital
Xining, Qinghai, 810001, China
the Second Hospital, Cheeloo College of Medicine, Shandong University
Jinan, Shandong, 250000, China
Qilu Hospital of Shandong University
Jinan, Shandong, 250012, China
Central Hospital Affiliated to Shandong First Medical University
Jinan, Shandong, 250013, China
People's Hospital of Donga County, Shandong Province
Liaocheng, Shandong, 252200, China
Qingdao Hospital University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)
Qingdao, Shandong, 266000, China
Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, 200025, China
Shanghai Putuo District Central Hospital
Shanghai, Shanghai Municipality, 200062, China
Shanghai General Hospital ( originally named Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200080, China
the second hospital of ShanXi medical unversity
Taiyuan, Shanxi, 030001, China
Xi'an People's Hospital
Xi’an, Shanxi, 710018, China
The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China
Chengdu, Sichuan, 610031, China
The First Affiliated Hospital of Chengdu Medical College
Chengdu, Sichuan, 610500, China
Chengdu Fifth People's Hospital
Chengdu, Sichuan, 611130, China
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, 300052, China
The Second Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, 300211, China
TEDA International Cardiovascular Hospital
Tianjin, Tianjin Municipality, 300457, China
Changdu People's Hospital of Tibet
Chamdo, Tibet, 854000, China
Xinjiang Uygur Autonomous Region People's Hospital
Ürümqi, Xinjiang, 830001, China
Yili Kazak Autonomous Prefecture Friendship Hospital
Yining, Xinjiang, 835000, China
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650031, China
Yan'an Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650051, China
Fuwai Yunnan Cardiovascular Hospital
Kunming, Yunnan, 650102, China
Zhejiang Hospital
Hangzhou, Zhejiang, 310000, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Hui Dong, MD
Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Target Duration
- 5 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
November 19, 2025
First Posted
November 26, 2025
Study Start
May 1, 2025
Primary Completion (Estimated)
August 31, 2029
Study Completion (Estimated)
August 31, 2029
Last Updated
November 26, 2025
Record last verified: 2025-11