NCT07107347

Brief Summary

Echocardiographic Assessment: Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS) if feasible All measurements averaged over 3 cardiac cycles (sinus) or 5 (AF) Follow-up data: ICU/hospital LOS Need for vasopressors/mechanical ventilation In-hospital and 30-day mortality

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
22mo left

Started Sep 2025

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress27%
Sep 2025Mar 2028

First Submitted

Initial submission to the registry

July 30, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 6, 2025

Completed
26 days until next milestone

Study Start

First participant enrolled

September 1, 2025

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2027

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2028

Last Updated

August 14, 2025

Status Verified

July 1, 2025

Enrollment Period

2 years

First QC Date

July 30, 2025

Last Update Submit

August 12, 2025

Conditions

Acute Pulmonary Embolism (PE)

Keywords

acute pulmonary embolism (PE)STEright ventricle strainspeckle tracking strain

Outcome Measures

Primary Outcomes (1)

  • Primary (main): Composite of in-hospital mortality, ICU admission >7 days, or need for mechanical circulatory/ventilatory support.

    30 day follow up

Secondary Outcomes (1)

  • Secondary outcome: Each individual component; echocardiographic parameters as predictors.

    30 day follow up

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

patients aged more than 18 years old with confirmed pulmonary embolism

You may qualify if:

  • Adults ≥18 years.
  • Confirmed acute PE (via CT pulmonary angiography).(4,6)
  • Echocardiography performed within 24 hours of diagnosis.

You may not qualify if:

  • Pre-existing significant RV dysfunction (e.g., due to chronic pulmonary hypertension, cor pulmonale or congenital heart disease).
  • History of coronary artery disease.
  • Impaired LV systolic function, ejection fraction \<50%.
  • Moderate to severe valvular heart disease.
  • Prior document of an episode of pulmonary embolism.
  • Poor acoustic window.
  • Hemodynamic instability

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assiut University Hospital

Asyut, Asyut Governorate, 25361, Egypt

Location

Central Study Contacts

Doaa Roshdy, assistant lecturer

CONTACT

+201024588594doaa.elenany@yahoo.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
assistant lecturer

Study Record Dates

First Submitted

July 30, 2025

First Posted

August 6, 2025

Study Start

September 1, 2025

Primary Completion (Estimated)

September 1, 2027

Study Completion (Estimated)

March 1, 2028

Last Updated

August 14, 2025

Record last verified: 2025-07

Locations

EG(1)