Prognostic Factors for Acute Pulmonary Embolism in Critically Ill Patients

NCT01839266 | Completed

• 1 other identifier: 4-2013-0034
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Acute pulmonary embolism (PE) is an important cause of in-hospital mortality and may be rapidly fatal if not diagnosed and treated. Despite recent advances in diagnostic and therapeutic modalities, it is still one of the important causes of hospital mortality. Previous several reports have described the variable outcome of patients with PE with reported mortality rate ranging from 8.1% (stable patients) to 25% (with cardiogenic shock) and 65% (post cardiopulmonary resuscitation). Nevertheless, there are no published studies from Korean hospitals that assessed the outcome of acute PE treated in the hospital with IV unfractionated heparin. We conducted this study to determine the outcome, risk factors, clinical characteristics and demographics of patients with acute PE and to identify possible demographic and clinical factors associated with prognosis.

Conditions

Acute Pulmonary Embolism (PE)

Keywords

acute PTE, prognostic factors

Outcome Measures

Primary Outcomes (1)

• prognostic factors of overall survival

  In-hospital all-cause mortality with acute pulmonary embolism(PE) treated in the hospital with IV unfractionated heparin

  change of acute pulmonary embolism(PE) for duration of hospital stay an expected average of 12 months

Study Arms (1)

acute PE survivor, acute PE nonsurvivor

acute PE survivor, acute PE nonsurvivor (in-hospital death)

Eligibility Criteria

• Age: 34 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with acute pulmonary embolism(PE) (diagnosed by CT) treated in the hospital with IV unfractionated heparin

You may qualify if:

• patients admitted to the Severance Hospital, Yonsei University Health System with primary diagnosis of PE between January 2008 and December 2012. (diagnosed by CT and treated in the hospital with IV unfractionated heparin)

You may not qualify if:

• diagnosis was prior to arrivalor
• anticoagulation was contraindicated
• diagnosis was not confirmed by CT

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Chief of ICUs, Severance Hospital, Yonsei University Health System

Seoul, Seoul, 120-752, South Korea

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2013
• First Posted: April 24, 2013
• Study Start: November 1, 2011
• Primary Completion: December 1, 2012
• Study Completion: April 1, 2013
• Last Updated: April 24, 2013

Record last verified: 2013-04

Locations

KR (1)