NCT07100639

Not Yet Recruiting

Singapore Population Research on Integrated exposoMe & Early...

Institute for Human Development and Potential (IHDP), Singapore Source

ClinicalTrials.gov

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Other study identifiers

Sponsor study identifier

2050-50

Secondary identifiers

MOH-001786-00

OTHER · NMRC, Singapore

Study Type

observational

Estimated enrollment

400

Locations

0 countries

Sites

N/A

Timeline

Study Start

August 6, 2025

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

March 31, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

April 1, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Brief Summary

Brief Summary The goal of this observational study is to learn how environmental factors, lifestyle choices, and social conditions affect the timing of menopause in Asian women aged 40-50 years living in Singapore. The main aims of the project are the following:

Do environmental pollutants and lifestyle exposures contribute to earlier menopause in Asian women?
What biological changes occur when women are exposed to harmful environmental factors during menopause transition? Participants will be followed for 18 months and will complete questionnaires about their health history, lifestyle, diet, and environmental exposures. Participants will provide blood, urine, stool, hair, and nail samples for laboratory analysis and undergo basic health assessments including weight, blood pressure, and bone density measurements. Participants will wear activity monitors and air pollution sensors for 7 days and attend follow-up visits at 6 months, 12 months, and 18 months to track changes in their health. This data will be obtained during the baseline visit.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: not yet recruiting
Estimated enrollment: 400 participants
Study completion date: April 1, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Listed locations: 0 countries · 0 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
July 27, 2025
Actual (reported)
First Posted
August 3, 2025
Actual (reported)
Study Start
August 6, 2025
Estimated (date passed)
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
March 31, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 1, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated: August 3, 2025
Status Verified: July 2025
Last Update Submitted: July 27, 2025

Conditions

Early Menopause

Keywords

early menopauseenvironmentpollutionexposome

Outcome Measures

Primary Outcomes (2)

Early menopause
18 months
Time to menopause onset
• Menopausal symptom severity score using standardized assessment tools
18 months

Study Arms (1)

SG-PRIME

no interventions

Eligibility Criteria

Age40 Years - 50 Years

Sexfemale(Gender-based eligibility)

Healthy VolunteersYes

Age GroupsAdult (18-64)

Sampling MethodNon-Probability Sample

Study Population

Women experiencing perimenopausal transition characterized by irregular menstrual patterns and hormonal fluctuations, stratified by age groups (40-45 years and 46-50 years) and ethnicity to ensure representative sampling of Singapore's multi-ethnic population.

You may qualify if:

Female participants aged 40-50 years No menstruation for the last 2 months or irregular menstrual cycles in the last 6 months Chinese, Malay, or Indian ethnicity Proficient in English language Planning to reside in Singapore for next 2 years Willing to provide informed consent and comply with study procedures

Sponsors & Collaborators

Institute for Human Development and Potential (IHDP), Singapore
Otherlead

MeSH Terms

Conditions

Primary Ovarian Insufficiency

Condition Hierarchy (Ancestors)

Ovarian DiseasesAdnexal DiseasesGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital DiseasesGonadal DisordersEndocrine System Diseases

Central Study Contacts

Narasimhan Kothandaraman, Ph.D

CONTACT

+65 64074057 Kothandaraman_Narasimhan@sics.-astar.edu.sg

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

July 27, 2025

First Posted

August 3, 2025

Study Start

August 6, 2025

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

March 31, 2028

You may not qualify if:

In menopause (12 consecutive months without menstruation) Currently pregnant or planning to conceive History of bilateral oophorectomy and/or hysterectomy Currently receiving hormone therapy, including estradiol replacement therapy or oral contraceptives Diagnosed with premature ovarian insufficiency before 40 years of age Diagnosis of autoimmune conditions and/or chromosomal abnormalities known to affect ovarian function Diagnosis of severe cognitive impairment and/or mental disorders Received cancer treatment in the past 12 months

Contact the study team to confirm eligibility.

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

April 1, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated

August 3, 2025

Record last verified: 2025-07

Source record

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Source: ClinicalTrials.gov.

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Registry identifier: NCT07100639
Data provider: ClinicalTrials.gov
Source updated: 2025-08-03
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:37:31 UTC

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (1)

SG-PRIME

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record