Spinal Metastasis as the First Presentation of Lung Malignancy: Clinical Characteristics and Postoperative Survival

NCT07100444 | Completed DMC

• 1 other identifier: lungfirstboneMetas
• Study Type: observational
• Target: 139
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare the clinical features and postoperative survival outcomes between patients with spinal metastasis as the initial manifestation of malignancy and those with spinal metastasis occurring after an established diagnosis of malignancy.

Conditions

Lung Cancers; Bone Metastasis

Keywords

lung cancers; bone metastasis; spinal metastasis; postoperative survival outcomes

Outcome Measures

Primary Outcomes (1)

• Postoperative Overall Survival

  Postoperative overall survival is defined as the time from the date of surgery for spinal metastasis to the date of death from any cause. Patients who are still alive at the last follow-up will be censored at that date. Survival status will be ascertained by clinical follow-up and/or review of medical records.

  From the date of surgery until death or last follow-up, up to 5 years

Study Arms (2)

Spinal Metastasis as the First Presentation of Lung Malignancy

It refers to patients who first present with symptoms such as pain or spinal cord compression caused by spinal metastasis, leading to the initial detection of bone metastasis, and are subsequently diagnosed with lung cancer.

lung cancer who subsequently developed spinal metastasis

It refers to patients with a history of treatment for primary lung cancer who subsequently developed spinal metastasis during the course of the disease.

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult patients diagnosed with lung cancer who have developed spinal metastasis. Participants will be selected from individuals treated at Guangdong Provincial People's Hospital. Eligible patients must have a diagnosis of lung cancer with spinal metastasis confirmed by pathological examination or imaging studies, and must have undergone surgical intervention for spinal metastasis.

You may qualify if:

• Age ≥ 18 years.
• Pathologically or radiologically confirmed diagnosis of lung cancer with spinal metastasis.
• Patients with spinal metastasis who underwent surgical intervention.
• Adequate medical records and follow-up data available.

You may not qualify if:

• Patients with spinal metastasis originating from non-lung primary tumors.
• Patients who did not receive surgical treatment for spinal metastasis.
• Incomplete clinical data or lost to follow-up.

Sponsors & Collaborators

• Guangdong Provincial People's Hospital: lead

Study Sites (1)

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510080, China

Location

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 24, 2025
• First Posted: August 3, 2025
• Study Start: January 1, 2018
• Primary Completion: March 30, 2025
• Study Completion: April 30, 2025
• Last Updated: August 3, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)