Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application

NCT07099963 | Recruiting

• 1 other identifier: 2026-4405
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.

Conditions

Thoracic; Surgery; Mechanical Ventilation; Hypercapnia; Acidosis; One Lung Ventillation (OLV); Smartphone Application

Outcome Measures

Primary Outcomes (1)

• Respiratory acidosis

  The frequency of respiratory acidosis on arterial blood gases after 20 minutes of mechanical ventilation (pH \< 7.35 and PaCO2 \> 45mmHg) measured by arterial blood gases

  20 minutes after initiation of one lung ventilation after lung isolation

Secondary Outcomes (6)

• Respiratory rate

  At the beginning of one lung ventilation during the surgery

• Acid-base disorder

  At the beginning of one lung ventilation during the surgery

• Number of participants with hemodynamic shock - hypotension

  Day 1

• Hospital length of stay

  Up to 90 days

• Mechanical Ventilation duration

  Up to 90 days

Study Arms (1)

Thoracic surgery

Patient managed with one lung ventilation

Other: one lung ventilation

Interventions

one lung ventilation OTHER

Arterial blood gases during one lung ventilation

Thoracic surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient undergoing thoracic surgery requiring intraoperative one-lung ventilation

You may qualify if:

• Adults (≥ 18 years old)
• Patients intubated and undergoing one-lung ventilation during thoracic surgery
• Volume-controlled ventilation mode used intraoperatively

You may not qualify if:

• Arterial blood gas data unavailable during one-lung ventilation
• Missing demographic data (sex, height, actual weight)

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Québec, Quebec, G1V4G5, Canada

RECRUITING

MeSH Terms

Conditions

Hypercapnia; Acidosis

Interventions

One-Lung Ventilation

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Acid-Base Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Respiration, Artificial; Airway Management; Therapeutics

Central Study Contacts

Francois Lellouche

CONTACT

1-418-656-8711; francois.lellouche@criucpq.ulaval.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 2, 2025
• First Posted: August 1, 2025
• Study Start: August 1, 2025
• Primary Completion: December 1, 2025
• Study Completion (Estimated): June 1, 2026
• Last Updated: August 6, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)