Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm

NCT07484828 | Not Yet Recruiting

• 1 other identifier: 2026-4504
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes. The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives: Determine how often acid-base disorders occur in these patients and describe their characteristics. Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm. The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings. This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients. Participation does not involve any intervention, as the study uses existing medical records.

Conditions

Mechanical Ventilation; Acid Base Disorder; Cardiac Arrest (CA); Cardiogenic Shock

Outcome Measures

Primary Outcomes (2)

• Acid-base disorder (respiratory acidosis)

  Presence of respiratory acisosis define by pH\< 7.35 and PaCO2 \> 45 mmHg

  Up to 4 hours after admission to the coronary care unit - First blood gas sample

• Acid-base disorder (respiratory alcalosis)

  Presence of respiratory alcalosis define by by pH\>7.45 and PaCO2 \< 35 mmHg

  Up to 4 hours after admission to the coronary care unit - First blood gas sample

Secondary Outcomes (10)

• Ventilator setting (Respiratory rate)

  Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample

• Ventilator setting (Tidal volume)

  Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample

• Acid-base disorder (metabolic acidosis)

  Up to 4 hours after admission to the coronary care unit - First blood gas sample

• Acid-base disorder (metabolic alcalosis)

  Up to 4 hours after admission to the coronary care unit - First blood gas sample

• Optimal acid-base result

  Up to 4 hours after admission to the coronary care unit - First blood gas sample

Study Arms (2)

Patient post cardiac arrest

Other: Initiation of mechanical ventilation

Patient with cardiogenic shock

Other: Initiation of mechanical ventilation

Interventions

Initiation of mechanical ventilation OTHER

Blood gases evaluation after initiation of mechanical ventilation

Patient post cardiac arrest; Patient with cardiogenic shock

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

post cardiac arrest or cardiogenic shock

You may qualify if:

• Adult (Age \>=18 years old)
• Under mechanical ventilation with endotracheal tube for :
• post cardiac arrest or cardiogenic shock
• \- Bood gases result availability up to 4 hours after coronary unit admission

You may not qualify if:

• Lack of patient anthropometric data (height and weight) available in the patient record
• No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
• Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval

Québec, Quebec, G1V4G5, Canada

Location

MeSH Terms

Conditions

Heart Arrest; Shock, Cardiogenic

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Myocardial Infarction; Myocardial Ischemia; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Shock

Central Study Contacts

Francois Lellouche

CONTACT

1-418-656-8711; francois.lellouche@criucpq.ulaval.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 5, 2026
• First Posted: March 20, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: March 20, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)