Surgical Management of Cesarean Scar Ectopic Pregnancy: Hysteroscopy & Laparoscopy Outcomes

NCT07095647 | Completed

• 1 other identifier: RC 9.6.2025
• Study Type: interventional
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

The study investigates the feasibility, safety, and outcomes of a simultaneous surgical approach for cesarean scar ectopic pregnancy (CSEP). CSEP is a prevalent and serious form of ectopic pregnancy requiring swift intervention. The research explores using hysteroscopy and laparoscopy concurrently to manage the CSEP and repair the uterine scar defect. The procedure involved hysteroscopic-guided evacuation and a double-layer laparoscopic repair, followed by a second hysteroscopy to confirm the repair's effectiveness.

Conditions

Cesarean Section Complications

Outcome Measures

Primary Outcomes (1)

• Success Rate of Hysteroscopy in Restoring the normal endometrial metrics, and removing any uterine defects.

  The proportion of patients who restored their normal endometrial metrics and removed any uterine scars during the study, reflecting the effectiveness of the applied Hystreoscopy regimens.

  6~7 months

Study Arms (1)

Cesarean Scar Ectopic Pregnancy Patients (CSEP)

OTHER

Patients presenting pregnant with a history of at least one previous Cesarean Section, and Transvaginal ultrasound documentation of Cesarean Scar Ectopic Pregnancy.

Procedure: Hysteroscopy

Interventions

Hysteroscopy PROCEDURE

Hysteroscopic-guided suction evacuation and double-layer laparoscopic repair of the niche were performed concomitantly and followed by second-look hysteroscopy to ensure the competence of the repair.

Cesarean Scar Ectopic Pregnancy Patients (CSEP)

Eligibility Criteria

• Age: 25 Years - 55 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with positive clinical and lab pregnancy diagnosis;
• Patients with history of at least one previous Cesarean section;
• Patients with Transvaginal ultrasound documenting Cesarean scar ectopic Pregnancy;

You may not qualify if:

• Patients with were extensive adhesions between the mass and the urinary bladder on MRI;
• Patients with myomas, polyps, endometrial hyperplasia, and cancers of the cervix or endometrium;
• Patients with a body mass index (BMI) of \>35kg/m2;
• Patients with previous abdominal surgeries with possible difficulties during laparoscopy;
• Patients with menstrual irregularities, or coagulation disorders.

Sponsors & Collaborators

• Benha University: lead

Study Sites (1)

Banha University

Banhā, El- Qalyobia, 13511, Egypt

Location

MeSH Terms

Interventions

Hysteroscopy

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Obstetrical and Gynecological; Diagnostic Techniques and Procedures; Diagnosis; Endoscopy; Diagnostic Techniques, Surgical; Minimally Invasive Surgical Procedures; Surgical Procedures, Operative; Obstetric Surgical Procedures; Gynecologic Surgical Procedures; Urogenital Surgical Procedures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Obstetrics & Gynecology, Faculty of Medicine

Study Record Dates

• First Submitted: July 30, 2025
• First Posted: July 31, 2025
• Study Start: October 1, 2024
• Primary Completion: April 15, 2025
• Study Completion: May 20, 2025
• Last Updated: July 31, 2025

Record last verified: 2025-07

Locations

EG (1)