Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
SIGN
2 other identifiers
interventional
294
1 country
2
Brief Summary
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2025
Typical duration for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 22, 2025
CompletedFirst Posted
Study publicly available on registry
July 30, 2025
CompletedStudy Start
First participant enrolled
October 3, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 1, 2027
April 27, 2026
April 1, 2026
2 years
July 22, 2025
April 21, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score
PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with a cannabis use composite score based on the Substance Use History and Timeline Follow-Back.
Baseline
Secondary Outcomes (1)
Correlation between PavCA bias score (out-of-scanner) and activation from the Cannabis Cue Reactivity Task (P-CAN)
Baseline
Study Arms (1)
Assessment group
EXPERIMENTALInterventions
Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.
Participants will have multiple visits during this study and fill out various surveys at these visits.
Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.
Eligibility Criteria
You may qualify if:
- years old at baseline
- Right-handed
- Medically/physically able to give informed consent
- English-speaking
- Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)
You may not qualify if:
- Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
- History of psychosis in self or first-degree relative
- Current treatment for substance use disorder
- Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
- Intelligence quotient (IQ) \< 70
- Lifetime history of head trauma with loss of consciousness \> 5 minutes
- Reliance on glasses to be able to read small text at a distance of approximately 30 inches
- Colorblindness
- MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Michiganlead
- National Institute on Drug Abuse (NIDA)collaborator
Study Sites (2)
Rachel Upjohn Building
Ann Arbor, Michigan, 48109, United States
University of Michigan
Ann Arbor, Michigan, 48109, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lora Cope, PhD
University of Michigan
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor Psychiatry
Study Record Dates
First Submitted
July 22, 2025
First Posted
July 30, 2025
Study Start
October 3, 2025
Primary Completion (Estimated)
October 1, 2027
Study Completion (Estimated)
October 1, 2027
Last Updated
April 27, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, ICF
- Time Frame
- The investigator/project team will contact ICPSR/NAHDAP 3-4 months before the required release date to determine if there would be lag time between data submission and ICPSR/NAHDAP's release of the data. ICPSR/NAHDAP permanently archives deposited files, supporting the data through changing technologies, new media, and data formats.
- Access Criteria
- The only requirements to access downloadable, de-identified data through ICPSR/NAHDAP are user registration and agreement to ICPSR/NAHDAP's Terms of Use, which require users to agree to not re-disseminate data, to use appropriate data citation, and to maintain human subjects protections. In the case of restricted-use, sensitive data, ICPSR/NAHDAP requires an application to access the data. As part of the application process, the data user's institution must enter into a Restricted Data Use Agreement with ICPSR/NAHDAP among other application components and data security requirements. Restricted data users are approved to access the data for a limited time period and in a controlled environment through the Virtual Data Enclave or a local computing environment that they secure themselves.
The scientific data collected will be preserved to enable sharing via Inter-university Consortium for Political and Social Research (ICPSR)/National Addiction \& HIV Data Archive Program (NAHDAP). The demographic, clinical, and psychometric raw and composite data will both be preserved and shared, and respondent identifiers will be removed and maintained in a secure file for future contact purposes. Where applicable, sensitive data will be managed using ICPSR/NAHDAP's restricted data dissemination practices to ensure the data are kept confidential.