Care Pathways and Disparities in Care for Older Patients With Cancer: Typology, Determinants and Effect on Prognosis ( PASSAGE )

NCT07092800 | Active Not Recruiting

• 2 other identifiers: APHP240996CSE-24-08_PASSAGE
• Study Type: observational
• Target: 75,000
• Locations: 1 country
• Sites: 1

Brief Summary

More than half of new cases of cancer in Europe in 2022 occurred in people aged over 70. In addition to cancer, the majority of older people have one or more illnesses that may interact with the treatment decision, cancer progression, tolerance and efficacy of treatments, quality of life, care pathway and survival. Furthermore, cancer treatments are most often evaluated in middle-aged subjects without severe disease, so the real-life management of older patients is often empirical. The general objective of the PASSAGE project is to assess the hospital care pathways of older patients with cancer treated at AP-HP by evaluating key elements of these pathways from both geriatric and therapeutic perspectives. Characterizing these care trajectories will help identify the most vulnerable patient profiles and potential disparities in access to care, with the goal of optimizing the management of elderly patients with cancer. The aims of this research are 1) to provide a better description of trends in the management of older cancer patients in routine clinical practice, and 2) to assess the impact of frailty, multimorbidity and the management of these patients on the prognosis of the disease.

Conditions

Tumor; Health Services Research; Causality; Geriatric Assessment; Aged; Cancer

Keywords

Frailty; care pathways; cancer; ageing

Outcome Measures

Primary Outcomes (1)

• type of care pathway

  The primary endpoint is the type of care pathway as identified by longitudinal clustering analysis of Electronic Health Record (EHR) data in the year following diagnosis (medical diagnoses, procedures, admissions, treatment received),.

  from cancer diagnosis during a year of follow-up

Study Arms (1)

Patients aged 70 or over with solid cancer

The following inclusion criteria will be applied to identify the study population: * Patients aged 70 or over, * Having at least one International Classification of Disease, 10th revision (ICD-10) code for solid cancer recorded as principal diagnostic or related, * During treatment in an AP-HP hospital, * Between 01/08/2017 and 31/07/2023.

Eligibility Criteria

• Age: 70 Years - 130 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

elderly cancer patients treated at AP-HP

You may qualify if:

• Patients aged 70 or over,
• Having at least one International Classification of Disease, 10th revision (ICD-10) for solid cancer recorded as principal diagnostic or related,
• During treatment in an AP-HP hospital,
• Between 01/08/2017 and 31/07/2023.

You may not qualify if:

• opposition to the reuse of healthcare data

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• Inria, the French National Institute for computer science and applied mathematics: collaborator
• CentraleSupelec School of Engineering: collaborator

Study Sites (1)

Henri Mondor Hospital

Créteil, VAL DE Marne, 94010, France

Location

MeSH Terms

Conditions

Neoplasms; Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2025
• First Posted: July 30, 2025
• Study Start: September 7, 2024
• Primary Completion (Estimated): August 31, 2028
• Study Completion (Estimated): August 31, 2028
• Last Updated: July 30, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)