Efficacy of LigaSure Versus Harmonic Scalpel US in Laparoscopic Appendectomy in Management of Acute Appendicitis

NCT07091110 | Completed DMC

• 1 other identifier: ZU-IRB#1419/17-6-2025
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Background Acute appendicitis is the most frequent abdominal surgical emergency worldwide, peaking in incidence between the second and third decade of life. Appendectomy was the only treatment for appendicitis for more than a century, and it is still the most common treatment. The surgical treatment for appendicitis is an appendectomy, which can be performed laparoscopically or openly. The purpose of the current study is to determine and measure the safety and effectiveness of laparoscopic appendectomy with LigaSure and harmonic US scalpels. Patients and methods: This research was carried out from January 2023 to January 2025, involved 60 patients who complained of acute lower abdominal pain in their right side, and were diagnosed with suspected acute appendicitis. Two groups of patients were formed: Group A had an appendectomy performed laparoscopically using a harmonic US scalpel, and group B underwent a laparoscopic appendectomy using LigaSure.

Conditions

Appendicitis Acute

Outcome Measures

Primary Outcomes (1)

• the average range of operating time for both groups

  Depending on the degree of difficulties experienced, the average range of operating time for both groups was reported.

  from January 2023 to January 2025

Secondary Outcomes (3)

• intraoperative complications

  from January 2023 to January 2025

• conversion to open surgery

  from January 2023 to January 2025

• postoperative complications

  from January 2023 to January 2025

Study Arms (2)

A

laparoscopic appendectomy using harmonic US scalpel and endoloop

Procedure: laparoscopic appendectomy

B

Laparoscopic appendectomy using LigaSure plus endoloop

Procedure: laparoscopic appendectomy

Interventions

laparoscopic appendectomy PROCEDURE

laparoscopic appendectomy

A; B

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This is a prospective comparative study for a total of 60 patients participated in this study, which ran from January 2023 to January 2025. Patients were complaining of acute right lower abdominal pain, after clinical examination, laboratory and radiological investigations diagnosed as acute appendicitis.

You may not qualify if:

• We excluded patients with complicated acute appendicitis, such as appendicular mass or abscess, patients with a history of previous multiple open abdominal surgeries, patients with economic factors, and also patients who preferred conventional, open appendectomy to the laparoscopic removal approach.

Sponsors & Collaborators

• Zagazig University: lead

Study Sites (1)

Zagazig University Hospitals

Zagazig, Sharqia Province, Egypt

Location

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor of general surgery

Study Record Dates

• First Submitted: July 21, 2025
• First Posted: July 29, 2025
• Study Start: January 1, 2023
• Primary Completion: January 1, 2025
• Study Completion: January 1, 2025
• Last Updated: July 29, 2025

Record last verified: 2025-07

Locations

EG (1)