Association Between Isokinetic Lower Extremity Muscle Strength and Bone Mineral Density in Elderly Women With and Without Osteoporosis

NCT07084857 | Completed

• 2 other identifiers: P.T.REC/012/005,927faculty of physical therapy
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

bone density and muscle strength appear to be more related to each other. Examining the association between muscle strength and bone health is very important in recognizing risk factors for lower extremity muscle weakness.

Conditions

Osteoporosis

Keywords

Osteoporosis; Bone Mineral Density; Isokinetic Strength;; Hip Muscles; Knee Muscles

Outcome Measures

Primary Outcomes (2)

• isokinetic strength of hip muscles

  isokinetic hip muscle stregth will be measured using Biodex system 3 Isokinetic Dynamometer

  one month

• Bone mineral density

  bone mineral density measured by dual energy x ray absorptiometry scan

  one month

Secondary Outcomes (1)

• isokinetic strength of knee muscles

  one month

Interventions

correlational analysis between BMD and isokinetic lower extremity strength OTHER

correlational analysis between BMD and isokinetic lower extremity strength

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Based on a sample size calculation via G Power software, a total of 70 participants will be required to participate in the study taking in consideration 20% drop out. A total 66 elderly women with ages range from 50 to 70 years will be involved in the study

You may qualify if:

• The group of OP (n=33) has femoral BMD T-scores below -2.5 diagnosed by DEXA scan according to the WHO \[8\] classification of BMD in 2003,
• The control group has normal BMD T-scores more than -1.

You may not qualify if:

• There was any neurological, musculoskeletal, rheumatologic, respiratory or cardiovascular problem.
• They were receiving medications that result in bone loss such as corticosteroids,
• They had vertigo, dizziness, or any vestibular problem,
• They had hyperthyroidism or hyperparathyroidism. 6- They actively participate in sports activities,
• They underwent previous surgery (e.g; joint replacement) or history of fractures of the lower extremity.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Azza Mohammed

Giza, 12511, Egypt

Location

MeSH Terms

Conditions

Osteoporosis

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Azza M Abdelmohsen, professor

  Cairo University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr

Study Record Dates

• First Submitted: May 20, 2025
• First Posted: July 25, 2025
• Study Start: February 8, 2025
• Primary Completion: March 28, 2025
• Study Completion: March 29, 2025
• Last Updated: April 8, 2026

Record last verified: 2026-04

Locations

EG (1)