Effect of Prone Position on Oxygen, Blood Gas, and Respiratory Parameters in Intensive Care Patients With COVID-19-induced ARDS

NCT06997666 | Completed

• 1 other identifier: 626
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial aimed to investigate the effect of the prone position on oxygen saturation, arterial blood gas parameters, and respiratory rate in intensive care patients diagnosed with COVID-19-induced Acute Respiratory Distress Syndrome (ARDS). A total of 90 patients (45 in the prone positioning group and 45 in the control group) were included. The intervention group received a 30-minute prone positioning procedure, while the control group received standard ICU care. Data were collected using a Demographic Information Form and clinical monitoring of respiratory and blood gas parameters across six time points over two days.

Conditions

COVID - 19; ARDS (Acute Respiratory Distress Syndrome)

Keywords

ARDS; COVID-19; Nursing; Blood gas values; Prone position

Outcome Measures

Primary Outcomes (1)

• Change in Oxygen Saturation (SpO₂)

  Measurement of arterial oxygen saturation (SaO₂), partial pressure of oxygen (PO₂), partial pressure of carbon dioxide (PCO₂), and pH from blood gas analysis to assess respiratory and metabolic effects of prone positioning.

  Baseline and six repeated measurements over two consecutive days

Secondary Outcomes (1)

• Change in Arterial Blood Gas Parameters (SaO₂, PO₂, PCO₂, pH)

  Baseline and six repeated measurements over two consecutive days

Other Outcomes (2)

• Change in Respiratory Rate

  Baseline and six repeated measurements over two consecutive days

• Change in Serum Lactate and Sodium Levels

  Baseline and six repeated measurements over two consecutive days

Study Arms (2)

Prone Position Group

EXPERIMENTAL

Patients in this group were placed in the prone position for 30 minutes once daily on two consecutive days. Oxygen saturation (SpO₂), blood gas parameters (SaO₂, PO₂, PCO₂, pH, lactate, sodium), and respiratory rate were measured before and after the intervention. No other treatment was altered.

Procedure: Prone Position

Supine Standard Care Group

NO INTERVENTION

Patients in this group received standard intensive care in the supine position. No additional interventions were applied. Oxygen saturation (SpO₂), blood gas parameters (SaO₂, PO₂, PCO₂, pH, lactate, sodium), and respiratory rate were measured at the same intervals as the intervention group.

Interventions

Prone Position PROCEDURE

Patients assigned to the Prone Position Group were placed in the prone position (lying face down) for 30 minutes once daily over two consecutive days while hospitalized in the ICU for COVID-19-induced ARDS. The intervention was performed between 12:30 and 13:00 under nurse supervision. Oxygen saturation, blood gas parameters (SaO₂, PO₂, PCO₂, pH, lactate, sodium), and respiratory rate were measured before and after each prone positioning session. The procedure was standardized across patients and no additional treatments were introduced during the intervention period.

Prone Position Group

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 40 years or older
• Admission to an intensive care unit (ICU)
• Confirmed diagnosis of COVID-19
• Developed Acute Respiratory Distress Syndrome (ARDS) due to COVID-19
• Intubated at the time of enrollment
• Provided informed verbal and written consent (or consent provided by legal representative)

You may not qualify if:

• Significant hearing or vision impairments affecting communication
• Cognitive impairment or inability to understand instructions
• Patient died during the course of the study
• Early discharge from intensive care before completion of all measurements
• Non-intubated patients whose level of consciousness could not be monitored

Sponsors & Collaborators

• Medet Korkmaz: lead

Study Sites (1)

Diyarbakır Provincial Health Directorate, 21000, Diyarbakır, Turkey

Diyarbakır, 21500, Turkey (Türkiye)

Location

Related Publications (1)

• Tekin V, Korkmaz M. The effect of prone position on oxygen saturation, blood gas parameters, and respiratory rate in intensive care patients with COVID-19-induced ARDS. Sci Rep. 2025 Nov 29;16(1):108. doi: 10.1038/s41598-025-28844-3.

  PMID: 41318642 DERIVED

MeSH Terms

Conditions

COVID-19; Acute Lung Injury

Interventions

Prone Position

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Lung Injury

Intervention Hierarchy (Ancestors)

Posture; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: May 26, 2025
• First Posted: May 30, 2025
• Study Start: March 1, 2021
• Primary Completion: August 30, 2021
• Study Completion: November 30, 2021
• Last Updated: May 30, 2025

Record last verified: 2025-05

Locations

TU (1)