Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning

NCT07083128 | Completed

• 1 other identifier: Temporal change in PIC
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences

Conditions

Mechanical Ventilation; Weaning From Mechanical Ventilation; Weaning Failure

Keywords

Parasternal thickening; failed weaning; extubation

Outcome Measures

Primary Outcomes (1)

• Accuracy of change in PIC-TF in predicting successful weaning from mechanical ventilation

  percentage of change in PIC TF in predicting weaning outcome (PIC TF30-PIC TF0)

  At baseline and 30 minutes after initiation of spontaneous breathing trial

Secondary Outcomes (1)

• Accuracy of change in PIC-TF to predict reintubation

  At baseline and 30 minutes after initiation of spontaneous breathing trial

Interventions

Parasternal intercostal thickening DEVICE

Temporal change in parasternal intercostal thickening fraction at initiation and 30 minutes of spontaneous breathing trial

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patient who are mechanically ventilated for 24 hours or more and ready for weaning

You may qualify if:

• \- Mechanically ventilated for 24 hours or more ready for weaning

You may not qualify if:

• Refusal Tracheostomized Inability to obtain ultrasound views patients with neuromuscular disease

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, Cairo Governorate, 6890, Egypt

Location

Related Publications (5)

• Helmy MA, Hasanin A, Milad LM, Mostafa M, Hamimy WI, Muhareb RS, Raafat H. Ability of parasternal intercostal muscle thickening fraction to predict reintubation in surgical patients with sepsis. BMC Anesthesiol. 2024 Aug 22;24(1):294. doi: 10.1186/s12871-024-02666-8.

  PMID: 39174907 RESULT

• Helmy MA, Milad LM, Hasanin AM, Mostafa M, Mannaa AH, Youssef MM, Abdelaziz M, Alkonaiesy R, Elshal MM, Hosny O. Parasternal intercostal thickening at hospital admission: a promising indicator for mechanical ventilation risk in subjects with severe COVID-19. J Clin Monit Comput. 2023 Oct;37(5):1287-1293. doi: 10.1007/s10877-023-00989-4. Epub 2023 Mar 24.

  PMID: 36961635 RESULT

• Helmy MA, Hasanin A, Milad LM, Mostafa M, Fathy S. Parasternal intercostal muscle thickening as a predictor of non-invasive ventilation failure in patients with COVID-19. Anaesth Crit Care Pain Med. 2022 Jun;41(3):101063. doi: 10.1016/j.accpm.2022.101063. Epub 2022 Apr 26. No abstract available.

  PMID: 35487407 RESULT

• Helmy MA, Magdy Milad L, Osman SH, Ali MA, Hasanin A. Diaphragmatic excursion: A possible key player for predicting successful weaning in patients with severe COVID-19. Anaesth Crit Care Pain Med. 2021 Jun;40(3):100875. doi: 10.1016/j.accpm.2021.100875. Epub 2021 Apr 30. No abstract available.

  PMID: 33940248 RESULT

• Adolf Helmy M, Magdy Milad L, Hasanin A, Mostafa M. The novel use of diaphragmatic excursion on hospital admission to predict the need for ventilatory support in patients with coronavirus disease 2019. Anaesth Crit Care Pain Med. 2021 Dec;40(6):100976. doi: 10.1016/j.accpm.2021.100976. Epub 2021 Nov 5.

  PMID: 34748940 RESULT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of anesthesia and critical care

Study Record Dates

• First Submitted: July 5, 2025
• First Posted: July 24, 2025
• Study Start: July 13, 2025
• Primary Completion: March 20, 2026
• Study Completion: March 20, 2026
• Last Updated: March 25, 2026

Record last verified: 2026-03

Locations

EG (1)