Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial

NCT07022704 | Recruiting

• 1 other identifier: Doxapram in COPD
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial

Conditions

COPD; Mechanical Ventilation; Weaning From Mechanical Ventilation

Keywords

COPD; Doxapram; Diaphragmatic excursion

Outcome Measures

Primary Outcomes (1)

• • Diaphragmatic excursion in mm

  before and 10 minutes after doxappram

Secondary Outcomes (2)

• Arterial blood gases

  before and 10 minutes after doxapram

• Respiratory rate

  before and 10 minutes after doxapram

Study Arms (1)

Doxapram

All patients will receive doxapram during spontaneous breathing trial

Drug: Doxapram

Interventions

Doxapram DRUG

Doxapram will be given as 1.5 mg/kg will be given 10 minutes after the initiation of SBT

Doxapram

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Chronic obstructive pulmonary diseases undergoing breathing trial

You may qualify if:

• Patients with moderate to severe chronic obstructive pulmonary disease undergoing spontaneous breathing trial

You may not qualify if:

• Refusal Allergy to doxapram neuromuscular disorders inability to evaluate the diaphragm

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, Cairo Governorate, 6890, Egypt

RECRUITING

Related Publications (5)

• Helmy MA, Magdy Milad L, Osman SH, Ali MA, Hasanin A. Diaphragmatic excursion: A possible key player for predicting successful weaning in patients with severe COVID-19. Anaesth Crit Care Pain Med. 2021 Jun;40(3):100875. doi: 10.1016/j.accpm.2021.100875. Epub 2021 Apr 30. No abstract available.

  PMID: 33940248 BACKGROUND

• Pourriat JL, Baud M, Lamberto C, Fosse JP, Cupa M. Effects of doxapram on hypercapnic response during weaning from mechanical ventilation in COPD patients. Chest. 1992 Jun;101(6):1639-43. doi: 10.1378/chest.101.6.1639.

  PMID: 1600786 BACKGROUND

• Oikawa S, Nomura H, Nishio M, Nagata R, Hata T. Doxapram hydrochloride aggravates adrenaline-induced arrhythmias accompanied by bidirectional ventricular tachycardia. ISRN Cardiol. 2014 Jan 9;2014:212045. doi: 10.1155/2014/212045. eCollection 2014.

  PMID: 24527224 BACKGROUND

• Rutka M, Palac M, Linek P. Diaphragmatic Mobility Loss in Subjects With Moderate to Very Severe COPD May Improve After In-Patient Pulmonary Rehabilitation. Respir Care. 2021 Feb;66(2):354. doi: 10.4187/respcare.08687. No abstract available.

  PMID: 33514664 BACKGROUND

• Scheibe N, Sosnowski N, Pinkhasik A, Vonderbank S, Bastian A. Sonographic evaluation of diaphragmatic dysfunction in COPD patients. Int J Chron Obstruct Pulmon Dis. 2015 Sep 11;10:1925-30. doi: 10.2147/COPD.S85659. eCollection 2015.

  PMID: 26392767 BACKGROUND

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Doxapram

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Pyrrolidinones; Pyrrolidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Central Study Contacts

Mina Helmy, MD

CONTACT

+201007174836; dr_mina20002010@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of anesthesia and critical care

Study Record Dates

• First Submitted: June 7, 2025
• First Posted: June 15, 2025
• Study Start: June 22, 2025
• Primary Completion: October 30, 2025
• Study Completion: November 1, 2025
• Last Updated: June 26, 2025

Record last verified: 2025-06

Locations

EG (1)