NCT07082335

Brief Summary

Colorectal cancer (CRC) often metastasizes to the liver, with synchronous metastases observed in 20% of cases. Surgical resection is the primary treatment, but the impact of simultaneous and staged resections on clinical outcomes remains unclear. This study employs propensity score matching (PSM) in a nationwide survey to compare clinical characteristics, complications, and survival, providing valuable insights for optimizing the management of colorectal liver metastases.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
679

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2019

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2019

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2021

Completed
3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2024

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

July 16, 2025

Completed
8 days until next milestone

First Posted

Study publicly available on registry

July 24, 2025

Completed
Last Updated

January 22, 2026

Status Verified

July 1, 2025

Enrollment Period

2 years

First QC Date

July 16, 2025

Last Update Submit

January 20, 2026

Conditions

Colorectal Cancer (CRC)

Outcome Measures

Primary Outcomes (2)

  • overall survival

    2 years

  • postoperative complications

    1 month

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

This nationwide multicenter retrospective cohort study enrolled colorectal cancer patients with simultaneous liver metastases treated at 18 tertiary hospitals in China between January 2019 and December 2021.

You may qualify if:

  • \) a histologically confirmed diagnosis of colorectal cancer with liver metastases; and 2) age ≥ 18 years

You may not qualify if:

  • \) extrahepatic metastases; and 2) ineligibility for curative surgical resection based on preoperative assessment.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Shanghai Tenth People Hospital, Yanchang Road, Jingan District, Shanghai,

Shanghai, Jingan, 200040, China

Location

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

July 16, 2025

First Posted

July 24, 2025

Study Start

January 1, 2019

Primary Completion

January 1, 2021

Study Completion

January 1, 2024

Last Updated

January 22, 2026

Record last verified: 2025-07

Locations

CN(1)