The Effect of Preoperative Biological Age on Hemodynamics and Renal Function

NCT07080086 | Completed

• 1 other identifier: KY-20240924-09
• Study Type: observational
• Target: 268,833
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background The aim of this study is to explore the potential value of preoperative biological age as a predictor of intraoperative hemodynamic changes and postoperative renal function injury. Methods Collect data using medical record system and surgical anesthesia system, and gather patients who have undergone surgery. Calculate the preoperative biological age of the patient and analyze the correlation between preoperative biological age accelerated aging and intraoperative hemodynamics and postoperative renal function damage.

Conditions

Acute Kidney Injury; Acute Kidney Disease; Intraoperative Hypotension; Post-induction Hypotension

Keywords

Intraoperative Hypotension; post-induction hypotension; Acute Kidney Injury; Acute kidney disease; Biological age; Biological aging

Outcome Measures

Primary Outcomes (4)

• The incidence ofn AKI

  Pateints encompasses an escalation in SCr of 50% or more, an increment of at least 0.3 mg/dL within 48 hours, or the need for RRT including haemodialysis, peritoneal dialysis, continuous renal replacement therapy, and kidney transplant. It was based on the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.

  Within 7 days postoperative,

• The incidence of AKD

  AKD was defined by a surge in SCr by more than 50%, or the initiation of RRT such as haemodialysis, peritoneal dialysis or continuous RRT.

  Within 8-90 days post-surgery

• The incidence of IOH

  IOH was defined as the presence of intraoperative epoque with MAP below 60 mmHg.

  During intraoperative period

• The incidence of PIH

  PIH was defined as at least one measurement of SAP below 90 mmHg.

  From induction of general anesthesia to 20 minutes post-induction.

Secondary Outcomes (3)

• The incidence of AKI 2+

  0-7 days post-surgery

• Cumulative duration of IOH and PIH

  During surgery

• The cumulative AUC of IOH and PIH.

  During surgery

Study Arms (1)

Biological age

PhenoAge and Klemera-Doubal method biological age (KDM-BA), were utilized. PhenoAge was calculated using the combination of chronological age and nine clinical biomarkers (albumin, SCr, glucose, C-reactive protein (CRP), lymphocyte percentage, mean cell volume (MCV), red blood cell distribution width (RDW), alkaline phosphatase, and white blood cell count (WBC)). KDM-BA was calculated by chronological age and nine clinical biomarkers (albumin, SCr, CRP, alkaline phosphatase, systolic blood pressure, blood urea nitrogen, forced expiratory volume in one second (FEV1), glycated haemoglobin, and total cholesterol).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing surgery with complete anaesthetic records

You may qualify if:

• Surgical pateints

You may not qualify if:

• (1) Lacking valid demographic information; (2) Lacking valid biological age; (3) Lacking blood pressure records

Sponsors & Collaborators

• Nanjing First Hospital, Nanjing Medical University: lead

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Yali Ge, MD

  The First Affiliated Hospital with Nanjing Medical University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 15, 2025
• First Posted: July 23, 2025
• Study Start: January 1, 2015
• Primary Completion: April 30, 2024
• Study Completion: July 30, 2024
• Last Updated: July 23, 2025

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share