NCT07077967

Brief Summary

Primary objective of this study is to introduce a modified luminous efficiency function that addresses the distinct total eye light transmittance of patients who underwent pseudophakic presbyopic correction with extended-depth of focus (EDOF) intraocular lenses (IOLs) implantations.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
7mo left

Started Oct 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress48%
Oct 2025Dec 2026

First Submitted

Initial submission to the registry

July 12, 2025

Completed
10 days until next milestone

First Posted

Study publicly available on registry

July 22, 2025

Completed
3 months until next milestone

Study Start

First participant enrolled

October 15, 2025

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 15, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2026

Last Updated

February 24, 2026

Status Verified

February 1, 2026

Enrollment Period

1 year

First QC Date

July 12, 2025

Last Update Submit

February 23, 2026

Conditions

Keywords

pseudophakic presbyopic correctionEDOF intraocular lenslight intensityeye light transmittancelight efficiency function

Outcome Measures

Primary Outcomes (1)

  • Minimum Required Illuminance Level (MRIL)

    Minimum Required Illuminance Level (MRIL) (in lx) at which participants reach their optimal Uncorrected Distance Visual Acuity.

    6 months postoperatively

Study Arms (2)

Study group

Patients who underwent uneventful pseudophakic presbyopic correction with yellow filter extended depth-of-focus (EDOF) IOLs (Vivity or Vivity toric, Alcon Laboratories, Inc., Fort Worth, TX, USA)

Procedure: Phacoemulsification with EDOF IOLs

Control group

Patients of similar age who underwent uneventful cataract surgery implanted with yellow filter monofocal or monofocal toric IOLs (SN60WF or SN6ATx, Alcon Laboratories, Inc., Fort Worth, TX, USA)

Interventions

Uneventful pseudophakic presbyopic correction with EDOF IOLs

Study group

Eligibility Criteria

Age45 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Presbyopic patients who underwent pseudophakic presbyopic correction with EDOF intraocular lens implantation

You may qualify if:

  • age between 45 to 75 years

You may not qualify if:

  • astigmatism \>1.00 diopters
  • glaucoma
  • former incisional eye surgery
  • corneal or fundus disease
  • diabetes mellitus
  • autoimmune diseases
  • neurological or psychiatric diseases
  • posterior capsule rupture or lens misalignment
  • postoperative uncorrected distance visual acuity \< 8/10.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital of Alexandroupolis

Alexandroupoli, Evros, 68100, Greece

RECRUITING

Related Publications (1)

  • Labiris G, Panagiotopoulou EK, Taliantzis S, Perente A, Delibasis K, Doulos LT. Lighting Standards Revisited: Introduction of a Mathematical Model for the Assessment of the Impact of Illuminance on Visual Acuity. Clin Ophthalmol. 2021 Nov 28;15:4553-4564. doi: 10.2147/OPTH.S326139. eCollection 2021.

MeSH Terms

Conditions

Presbyopia

Interventions

Phacoemulsification

Condition Hierarchy (Ancestors)

Refractive ErrorsEye Diseases

Intervention Hierarchy (Ancestors)

Cataract ExtractionRefractive Surgical ProceduresOphthalmologic Surgical ProceduresSurgical Procedures, OperativeUltrasonic Surgical Procedures

Study Officials

  • Georgios Labiris, MD, Prof

    Democritus University of Thrace

    STUDY CHAIR

Central Study Contacts

Eirini - Kanella Panagiotopoulou, MD, MSc, PhD

CONTACT

Georgios Labiris, MD, Prof

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
6 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Ophthalmology

Study Record Dates

First Submitted

July 12, 2025

First Posted

July 22, 2025

Study Start

October 15, 2025

Primary Completion (Estimated)

October 15, 2026

Study Completion (Estimated)

December 15, 2026

Last Updated

February 24, 2026

Record last verified: 2026-02

Locations