Effects of Upgrading From Right Ventricular Pacing to Cardiac Resynchronization Therapy and Comparison With Dual-Chamber Defibrillator

NCT07077928 | Completed

• 1 other identifier: Bursa PH CRT Upgrade
• Study Type: observational
• Target: 307
• Locations: 1 country
• Sites: 1

Brief Summary

Patients who consecutively underwent de novo CRT implantation, CRT upgrade, and DDDR ICD implantation at the Cardiology Clinic of Bursa Postgraduate Hospital between January 2019 and December 2023 according to the European Society of Cardiology (ESC) guideline criteria were included in the study.

Conditions

Heart Failure; Ventricular Arrhythmias and Cardiac Arrest

Keywords

Heart failure; Cardiac Resynchronization Therapy; Upgrade; Defibrillator; Pacemaker

Outcome Measures

Primary Outcomes (1)

• All cause mortality and hospitalization for heart failure

  24 months

Interventions

Pacemaker upgrade DEVICE

CRT upgrade

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who consecutively underwent de novo CRT implantation, CRT upgrade, and DDDR ICD implantation at the Cardiology Clinic Heart failure group in Sinus rhythm

You may qualify if:

• De novo CRT group:
• Sinus rhythm,
• age higher than 18,
• EF lower than 35%,
• New York Heart Association (NYHA) class II-IV,
• QRS \>130 ms,
• patients with atrial fibrillation (AF) who converted to sinus rhythm and who remained symptomatic despite 3-6 months of guideline-directed medical therapy.
• CRT upgrade group:
• Sinus rhythm,
• age higher than 18,
• EF lower than 35%,
• NYHA class II-IV,
• QRS duration \>130 ms with RV pacing,
• \> 20% RV pacing rate,
• patients with AF who converted to sinus rhythm, at least 6 months since pacemaker implantation, and symptomatic despite 3-6 months of guideline directed medical therapy.

You may not qualify if:

• patients with atrial fibrillation
• LV EF higher than 50 %
• NYHA Class 1
• Patients with active infection or cancer

Sponsors & Collaborators

• Bursa Postgraduate Hospital: lead

Study Sites (1)

Bursa Yüksek İhtisas Hastanesi

Bursa, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Heart Failure; Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 24 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Doctor

Study Record Dates

• First Submitted: July 12, 2025
• First Posted: July 22, 2025
• Study Start: January 1, 2019
• Primary Completion: December 1, 2023
• Study Completion: December 31, 2023
• Last Updated: July 22, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)