Healing of Corneal Incision After Cataract Surgery in Diabetic Patients

NCT07076420 | Completed

• 1 other identifier: 20250122
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this observational study was to understand the healing of corneal incision after cataract surgery in diabetic patients and its influencing factors. The main questions it aims to answer are: Is corneal incision healing worse in diabetic patients after cataract surgery than in non-diabetic patients? What are the factors affecting corneal incision healing after cataract surgery in diabetic patients? The results of anterior segment optical coherence tomography before and after cataract surgery in cataract patients with or without diabetes will be collected and analyzed.

Conditions

Diabetes; Cataract

Outcome Measures

Primary Outcomes (2)

• volume of half cornea with surgical incision

  Before surgery; 1 week after surgery; 1 month after surgery

• Defect of corneal incision healing

  Opening of internal orifice; Endothelial dislocation; Descemet's membrane detachment

  1 week after surgery; 1 month after surgery

Study Arms (2)

Diabetes group

Control group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who were initially diagnosed with cataract and treated with phacoemulsification and intraocular lens implantation at Zhongnan Hospital of Wuhan University from April 1, 2024 to December 31, 2024.

You may qualify if:

• Patients who experience blurred vision and painless visual acuity decline, and are diagnosed with cataract (with or without diabetes) through reliable intraocular pressure, visual acuity and slit lamp examinations, and for whom phacoemulsification of cataract can be considered.

You may not qualify if:

• Use multiple eye drops before surgery.
• Complicated by other eye diseases that affect corneal healing, such as keratitis, uveitis, glaucoma, etc.
• Moderate to severe dry eye.
• History of eye surgery.
• Moderate to severe dry eye.
• Grade 5 nuclear cataract.
• Severe systemic diseases (such as chronic renal failure requiring dialysis, severe neurological diseases, immune diseases), pregnancy or lactation.

Sponsors & Collaborators

• Zhongnan Hospital: lead

Study Sites (1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430071, China

Location

MeSH Terms

Conditions

Diabetes Mellitus; Cataract

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Lens Diseases; Eye Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2025
• First Posted: July 22, 2025
• Study Start: April 1, 2024
• Primary Completion: December 31, 2024
• Study Completion: January 15, 2025
• Last Updated: July 22, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)