Trials Sponsors Conditions Drugs Pricing

Conditions

Pregnancy Labor and Delivery Labor Analgesia

Keywords

epidurallabor analgesiapregnancyobstetric anesthesia

Outcome Measures

Primary Outcomes (1)

Numerical Pain score
Numerical pain score using a discrete range from 0 (no pain) to 10 (most severe pain).
30 mins post-intervention

Study Arms (1)

Observational Cohort

EXPERIMENTAL

Patients with singleton vertex pregnancies in active labor (spontaneous or after induction of labor), with a cervical dilatation between 1 and 7cm who are requesting neuraxial labor analgesia, Age =\>18 yrs

Drug: Ropivacaine + Fentanyl

Interventions

Ropivacaine + FentanylDrug

A standard epidural admixture - 0.1% Ropivacaine + 2 mcg/ml fentanyl - will be used.

Observational Cohort

Named ingredients in these interventions

Linked from the registry description. Each source intervention is retained as reported.

Fentanyl
In: Ropivacaine + Fentanyl
Ropivacaine
In: Ropivacaine + Fentanyl

Registry intervention entries

These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.

Grouped treatment entry
Ropivacaine + Fentanyl
The registry names several treatments. This does not confirm that participants received them together or that they form a single product.
View registry record

Eligibility Criteria

Age18 Years+

Sexfemale(Gender-based eligibility)

Gender Eligibility DetailsPregnant birthing patients

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Patients with singleton vertex pregnancies in active labor (latent or spontaneous labor or after induction of labor)

Sponsors & Collaborators

University of California, San Francisco
Otherlead

Study Sites (1)

University of California, San Francisco

San Francisco, California, 94158, United States

RECRUITING

Alexander ButwickCONTACT415-514-3757 alexander.butwick@ucsf.edu

Related Publications (3)

Chau A, Bibbo C, Huang CC, Elterman KG, Cappiello EC, Robinson JN, Tsen LC. Dural Puncture Epidural Technique Improves Labor Analgesia Quality With Fewer Side Effects Compared With Epidural and Combined Spinal Epidural Techniques: A Randomized Clinical Trial. Anesth Analg. 2017 Feb;124(2):560-569. doi: 10.1213/ANE.0000000000001798.
PMID: 28067707BACKGROUND
Song Y, Song Y, Sheng Z, Zhao Q, Liu W, Li Y, Zang Y, Xu Z, Liu Z. Exploration of the optimal programmed intermittent epidural bolus volume with the dural puncture epidural technique for labour analgesia: a biased-coin up-and-down sequential allocation study. Can J Anaesth. 2025 Feb;72(2):254-261. doi: 10.1007/s12630-024-02855-6. Epub 2024 Oct 21.
PMID: 39433721BACKGROUND

MeSH Terms

Interventions

RopivacaineFentanyl

Intervention Hierarchy (Ancestors)

AnilidesAmidesOrganic ChemicalsAniline CompoundsAminesPiperidinesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Study Officials

Alexander Butwick, MBBS, FRCA, MS
University of California, San Francisco
PRINCIPAL INVESTIGATOR

Central Study Contacts

Alexander Butwick, MBBS, FRCA, MS

CONTACT

415-514-3757 alexander.butwick@ucsf.edu

Study Design

Study Type: interventional
Phase: phase 3
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

July 7, 2025

First Posted

July 22, 2025

Study Start

October 24, 2025

Actual (reported)

Ropivacaine and Fentanyl for Labor Epidural Initiation

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Observational Cohort

Interventions

Named ingredients in these interventions

Registry intervention entries

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (3)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Observational Cohort

Interventions

Named ingredients in these interventions

Registry intervention entries

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (3)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations