Trials Sponsors Conditions Drugs Pricing

Conditions

Circadian Clock Obesity Post Menopause Sarcopenia Type 2 Diabetes

Keywords

Timing of eatingTiming of exerciseMuscle FunctionMetabolic HealthObesityMenopausewomen

Outcome Measures

Primary Outcomes (1)

Change in skeletal muscle function
Change in skeletal muscle function, assessed by 30-CTS score at inclusion (baseline) and 12 weeks after diet/exercise program; This test is used to assess lower limb strength. The score corresponds to the total number of standing positions correctly performed within the allotted 30 seconds.
4 years

Secondary Outcomes (21)

Change in muscle function
4 years
• Change in M value measured by hyperinsulinemic euglycemic clamp
4 years

Study Arms (3)

Diet control (no chrono restriction) + exercise performed in the morning

EXPERIMENTAL

Patients following a standard antidiabetic diet combined with morning exercise

Other: Antidiabetic diet (control)Other: Physical activity in the morning

eTRE (chrono restriction) + exercise performed in the morning

EXPERIMENTAL

Patients following the eTRE program combined with physical exercise performed in the morning

Other: eTRE dietOther: Physical activity in the morning

eTRE (chrono restriction) + exercise performed in the afternoon

EXPERIMENTAL

Interventions

Antidiabetic diet (control)Other

Standard antidiabetic diet

Diet control (no chrono restriction) + exercise performed in the morning

eTRE dietOther

eTRE for a total duration of 12 weeks. During the eTRE, volunteers will have to eat and drink (meals + snacks, medication) exclusively during an 8-hour period which will extend between 6 a.m. (flexible: or 7 a.m. or 8 a.m.) in the morning and 2 p.m. (depending on the chosen start time: or 3 p.m. or 4 p.m.), which corresponds to a fasting period of 16 hours per day

Eligibility Criteria

Age45 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Post-menopausal women (amenorrhea for at least 12 months, confirmed by gonadotrophins measures)
Age range 45-70 years

Sponsors & Collaborators

University Hospital, Toulouse
Otherlead

Study Sites (1)

Rangueil Hospital

Toulouse, France, 31000, France

MONTASTIER Emilie, MDCONTACT5 61 32 30 41 ext. +33 montastier.e@chu-toulouse.fr

TOMASIK AudreyCONTACT5 61 77 85 97 ext. +33 tomasik.a@chu-toulouse.fr

MONTASTIER Emilie, MDPRINCIPAL INVESTIGATOR

MeSH Terms

Conditions

ObesitySarcopeniaDiabetes Mellitus, Type 2

Interventions

Exercise

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsMuscular AtrophyNeuromuscular ManifestationsNeurologic Manifestations

Study Officials

MONTASTIER Emilie, MD
University Hospital, Toulouse
PRINCIPAL INVESTIGATOR

Central Study Contacts

MONTASTIER Emilie, MD

CONTACT

5 61 32 30 41 montastier.e@chu-toulouse.fr

TOMASIK Audrey

CONTACT

5 61 77 85 97

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: NONE
Purpose: PREVENTION
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

June 24, 2025

First Posted

July 20, 2025

Study Start

September 15, 2026

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

July 15, 2029

Estimated

Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (21)

Study Arms (3)

Diet control (no chrono restriction) + exercise performed in the morning

eTRE (chrono restriction) + exercise performed in the morning

eTRE (chrono restriction) + exercise performed in the afternoon

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (21)

Study Arms (3)

Diet control (no chrono restriction) + exercise performed in the morning

eTRE (chrono restriction) + exercise performed in the morning

eTRE (chrono restriction) + exercise performed in the afternoon

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations