Arterial Stiffness in Individuals With Breast Cancer

NCT07070778 | Recruiting

• 1 other identifier: 2025/5-39
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to evaluate vascular toxicity induced by anthracyclines and other anticancer drugs and to measure arterial stiffness in women with breast cancer and, in addition, to evaluate the acute and chronic arterial stiffness responses of upper extremity aerobic exercise training.

Conditions

Arterial Stiffness; Aerobic Exercise; Breast Cancer

Keywords

breast cancer; Aerobic exercise training; Arterial Stiffness

Outcome Measures

Primary Outcomes (1)

• Arterial Stiffness

  Arterial stiffness will be assessed noninvasively using the pulse wave velocity (PWV) technique with the Mobil-O-GRAPH (TG) (I.E.M., Stolberg, Germany), an oscillometer-based device. Pulse wave velocity, augmentation pressure, reflection magnitude, agumentation index parameters will be recorded.

  one years

Secondary Outcomes (3)

• Comorbidity Assessment

  one year

• Maximal Arm Exercise Capacity

  one year

• Cardiovascular Disease Risk Scoring

  one year

Study Arms (1)

Upper Extremity Aerobic Exercise

OTHER

Participants will only receive a 12-week upper extremity aerobic exercise training program.

Other: Upper Extremity Aerobic Exercise Training Program

Interventions

Upper Extremity Aerobic Exercise Training Program OTHER

12 weeks of supervised upper limb aerobic exercise training, 3 sessions per week, 25 minutes per session.

Upper Extremity Aerobic Exercise

Eligibility Criteria

• Age: 40 Years - 69 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• To be between the ages of 40-69,
• Baseline left ventricular ejection fraction (LVEF) \>50%,
• Absence of coronary artery disease and haemodynamically significant valvular heart disease,
• Absence of carotid atherosclerotic plaques,
• Volunteering to participate in the research,
• At least 15 months after breast cancer surgery,
• No problems in reading and/or understanding the scales and being able to co-operate with the tests.
• Physically inactive (60 minutes of structured exercise per week \<).

You may not qualify if:

• Presence of active infection,
• Presence of bilateral breast cancer,
• History of surgical, neurological or orthopaedic problems that may affect upper extremity functionality other than breast cancer surgery,
• Having a neurological disease or other clinical diagnosis that may affect cognitive status,
• Left ventricular dysfunction and severe liver and kidney dysfunction before starting chemotherapy
• Musculoskeletal and neurological disease that may affect exercise performance, symptomatic heart disease, previous lung surgery and malignant disease.
• Presence of unstable hypertension or diabetes mellitus.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, State, 06100, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Melda Saglam, PhD

  Hacettepe University

  STUDY CHAIR

• Ebru Calik Kutukcu, PhD

  Hacettepe University

  STUDY DIRECTOR

Central Study Contacts

Ebru Calik Kutukcu, PhD

CONTACT

+903123051576; ebru.calik@hacettepe.edu.tr

Naciye Vardar-Yagli, PhD

CONTACT

+03123051576; naciyevardar@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The study consists of one group: this group performs upper extremity aerobic exercise training.

Study Record Dates

• First Submitted: July 9, 2025
• First Posted: July 17, 2025
• Study Start: July 8, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: December 29, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)