To Study the Mortality Outcome of Controlled Blood Pressure Participants

NCT07067632 | Active Not Recruiting

• 1 other identifier: DejthidaNathaphong
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials. To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

Conditions

Hypertension (HTN); Valid MeSH Conditions

Keywords

hypertension; cardiovascular death

Outcome Measures

Primary Outcomes (1)

• All-cause mortality

  All cause mortality by controlable hypertension treatment

  100 year

Study Arms (2)

Antihypertensive treatment

Participants assigned to interventions (pharmacological, device-based, or lifestyle) directed at lowering blood pressure or Antihypertensive agents, Blood pressure-lowering treatment, Antihypertensive therapy.

Drug: Antihypertensive treatment

Control/Comparator

Participants receiving placebo, standard of care, or no intervention

Interventions

Antihypertensive treatment DRUG

Any intervention (pharmacological, device-based, lifestyle) intentionally directed at lowering BP Control groups receiving placebo, standard of care, or no intervention

Also known as: device-based blood pressure lowering, lifestyle modification

Antihypertensive treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults ≥18 years with diagnosed hypertension Blood pressure controlled at target values defined by the study (e.g., \<140/90 mmHg or \<130/80 mmHg) Any comorbidity allowed unless the study focuses on pregnancy or pediatric population

You may qualify if:

• Adults ≥18 years with diagnosed hypertension
• Blood pressure controlled at target values defined by the study (e.g., \<140/90 mmHg or \<130/80 mmHg)
• Any comorbidity allowed unless the study focuses on pregnancy or pediatric population

You may not qualify if:

• Observational or retrospective studies
• Pediatric or pregnant participants
• Case reports, editorials, or conference abstracts without full data
• Studies not reporting mortality outcomes separately for controlled BP

Sponsors & Collaborators

• DejthidaNathaphong: lead

Study Sites (1)

Nathaphong

Bangkok, 10110, Thailand

Location

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Nathaphong Dejthida, MD

  DejthidaNathaphong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 6, 2025
• First Posted: July 16, 2025
• Study Start: July 1, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): February 1, 2027
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR, ANALYTIC CODE

Locations

TH (1)