Effects of Balance and Muscle Strength in Knee Osteoarthritis

NCT07066215 | Completed

• 1 other identifier: KA25-1
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Knee osteoarthritis (OA) is a chronic and progressive joint disease characterized by the degeneration of articular cartilage, subchondral bone sclerosis, and the formation of osteophytes. This condition leads to joint pain and stiffness, negatively affecting individuals' quality of life. Joint stiffness, decreased quadriceps strength, and impaired proprioceptive sensation result in functional limitations. Due to these symptoms, individuals experience difficulties in performing daily activities such as rising from a chair, walking, and climbing stairs. The aim of this study is to evaluate the effects of balance, and muscle strength on functional capacity in patients with knee osteoarthritis.

Conditions

Primary Knee Osteoarthritis

Outcome Measures

Primary Outcomes (5)

• Muscle strength

  Muscles strength measurement with 5 time sit-to-stand test

  Baseline

• Balance

  Biodex Balance System will be used for postural stability evaluation. Lower scores indicate better stability and higher scores mean poor balance.

  Baseline

• 6-minute walk test

  Walking distance will be measured

  Baseline

• Stair climb test

  Test completion time will be evaluated

  Baseline

• Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

  Function subscale consisting of 17 items will be used for evaluation. Higher scores indicate greater functional limitation.

  Baseline

Eligibility Criteria

• Age: 45 Years - 75 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who have diagnosed primary knee osteoarthritis will be included

You may qualify if:

• Primary knee osteoarthritis

You may not qualify if:

• Previous surgery in the lower extremity
• Neuromuscular disease
• Vestibular pathology
• Physiotherapy intervention or intra-articular injection within the last 6 months

Sponsors & Collaborators

• Bezmialem Vakif University: lead

Study Sites (1)

Bezmialem Vakif University

Istanbul, Eyup, Turkey (Türkiye)

Location

Study Officials

• Kubra Alpay, PhD

  Bezmialem Vakif University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Physiotherapy and Rehabilitation Department

Study Record Dates

• First Submitted: July 14, 2025
• First Posted: July 15, 2025
• Study Start: August 1, 2025
• Primary Completion: February 28, 2026
• Study Completion: March 13, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Locations

TU (1)