NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison

NCT07064642 | Completed

• 2 other identifiers: EKO-NLR-20252023/122
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between \[September 1, 2022\] and \[April 1, 2023\]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.

Conditions

Tympanoplasty; Myringoplasty; Neutrophil-to-Lymphocyte Ratio; Low-flow Anesthesia; High-flow Anesthesia

Keywords

Anesthesia high-flow; Anesthesia low-flow; Neutrophil-lymphocyte ratio; Systemic inflammatory response

Outcome Measures

Primary Outcomes (1)

• Postoperative neutrophil-to-lymphocyte ratio (NLR)

  The neutrophil-to-lymphocyte ratio measured from blood samples taken immediately after surgery to assess the systemic inflammatory response in patients undergoing tympanoplasty or myringoplasty with low-flow or high-flow anesthesia.

  Within 1 hour postoperatively (Day 0)

Study Arms (2)

Low-flow anesthesia group

Low-flow anesthesia group 0.75 L/min : Patients who underwent tympanoplasty or myringoplasty under low-flow anesthesia technique. The anesthetic gas flow rate was maintained at low levels throughout the procedure to evaluate its effects on systemic inflammation and hemodynamics.

High-flow anesthesia group

High-flow anesthesia group 3 L/min : Patients who underwent tympanoplasty or myringoplasty under high-flow anesthesia technique. The anesthetic gas flow rate was maintained at high levels throughout the procedure to compare its impact on inflammatory response and postoperative outcomes.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective study evaluated patients who underwent tympanoplasty or myringoplasty surgery at the operating rooms of Karadeniz Technical University Faculty of Medicine between September 1, 2022, and April 1, 2023. Participants were excluded based on the following criteria: age under 18 or over 75 years, incomplete clinical data, body mass index (BMI) \<18.5 kg/m² or \>29.9 kg/m², presence of neurological disorders, and a history of renal or hepatic failure. A total of 59 patients aged between 18 and 75 years, with ASA (American Society of Anesthesiologists) physical status scores of I-III and BMI values between 18.5 and 29.9 kg/m², were initially included in the study. Following the exclusion of nine patients with missing data, the final study population consisted of 50 individuals.

You may qualify if:

• Adults aged between 18 and 75 years
• American Society of Anesthesiologists (ASA) physical status classification I to III
• Body Mass Index (BMI) between 18.5 and 29.9 kg/m²

You may not qualify if:

• Age below 18 or above 75 years
• Incomplete or missing clinical data
• BMI less than 18.5 kg/m² or greater than 29.9 kg/m²
• Presence of neurological disorders
• History of renal or hepatic failure

Sponsors & Collaborators

• Eda KAZANÇ ÖZDEN: lead

Study Sites (1)

Karadeniz Technical University Faculty of Medicine Hospital

Trabzon, Trabzon, 61080, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident Doctor in Anesthesiology, Sponsor-Investigator

Study Record Dates

• First Submitted: July 3, 2025
• First Posted: July 15, 2025
• Study Start: July 20, 2023
• Primary Completion: August 20, 2023
• Study Completion: September 20, 2023
• Last Updated: July 17, 2025

Record last verified: 2025-07

Locations

TU (1)