Clinical Evaluation of (TCAF) Versus (CAF) Combined With Connective Tissue Graft in the Treatment of Multiple RT2 Gingival Recession Sites

NCT07064603 | Not Yet Recruiting

• 1 other identifier: 2025-17-1
• Study Type: interventional
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

the aim of the study is to evaluate the changes in gingival recession depth reduction following, treatment of multiple RT2 recession with tunnel coronal advanced flap in comparison to coronal advanced flap, both combined with connective tissue graft

Conditions

Gingival Recession, Plastic Surgery

Outcome Measures

Primary Outcomes (1)

• Gingival recession depth reduction (GRD)

  ONE YEAR

Secondary Outcomes (9)

• Percentage of mean root coverage (MRC %)

  one year

• Percentage of complete root coverage (CRC%)

  one year

• Gingival Recession width

  one year

• Keratinized tissue width (KTW)

  one year

• Probing pocket depth

  one year

Study Arms (2)

CORONAL ADVANCED FLAP WITH CONNECTIVE TISSUE GRAFT

ACTIVE COMPARATOR

The surgical papillae will be elevated using split thickness manner while maintaining the blade in a nearly parallel position to the root. * The flap apical to the exposed root will be elevated in a full-thickness The full thickness flap covers the avascular root exposure. * The releasing vertical incisions will be elevated protect the underlying bone in the lateral areas of the flap. * The part of the flap apical to bone exposure will be elevated by split-thickness, this step will be done so it is possible to move the flap passively in the coronal direction. * To permit the coronal advancement of the flap, all muscle insertions present in the thickness of the flap will be eliminated. This will be done by keeping the blade parallel to the external mucosal surface. The connective tissue graft, is harvested from the hard palate (donor site) then it will be sutured in the surgical recipient site then covered by the coronal advancement of the flap and suturing it.

Procedure: TCAF

Tunnel coronal advanced flap with connective tissue graft

EXPERIMENTAL

only one surgical papilla will be elevated. The papilla chosen for incision must be with the least interproximal attachment loss. A slightly divergent vertical incision extending beyond the mucogingival junction then a horizontal incision at a distance equal to the recession depth plus 1 mm apical to the papilla tip. The other papillae integrity is preserved , and will be detached using tunneling miniblades and papilla elevator. The flap will be tunneled till the planned papilla .Connective tissue graft will be harvested the graft will be inserted underneath the flap and tunneled below the non-incised papillae. The TCAF is coronally advanced and stabilized 2 mm above the CEJ with sling and simple interrupted sutures at the level of the papillae and simple interrupted sutures for the vertical incision Further coronal advancement of the tunneled papilla with a suspended suture around the with a composite stop

Procedure: TCAF

Interventions

TCAF PROCEDURE

tunnel coronal advanced flap

CORONAL ADVANCED FLAP WITH CONNECTIVE TISSUE GRAFT; Tunnel coronal advanced flap with connective tissue graft

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients age 18 years or older.
• Multiple adjacent recession defect classified as RT2.
• Patients with healthy systemic condition (Mazzotti et al., 2023).
• An esthetic concern or hypersensitivity associated with GR
• The gingival recessions must have at least 1.5 mm of KTW.
• Presence of an identified CEJ (A step ≤ 1mm of the CEJ level)

You may not qualify if:

• Full-mouth plaque and bleeding scores \>20 (O'Leary et al., 1972)
• Patients with active periodontal disease;
• Intake of any medications known to affect gingival homeostasis or to interfere with wound healing
• Pregnancy and nursing women
• Smokers: a contraindication for any plastic periodontal surgery (Khuller, 2009).
• Absence of cervical restorations, crowding or malalignment

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Conditions

Gingival Recession

Condition Hierarchy (Ancestors)

Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy

Central Study Contacts

May Mohamed Kamal

CONTACT

01063392983; may.kamal@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: July 1, 2025
• First Posted: July 14, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: July 16, 2025

Record last verified: 2025-07