Curcumin & Astaxanthin for Lowering Triglyceride Readings and Inflammation

NCT07063056 | Recruiting

• 1 other identifier: TgStudy
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Two dietary supplements are each being compared to a placebo for the ability to help maintain triglycerides in the normal range. The subjects will be adult men and women with moderately high TG values. Serum triglycerides will be measured before and after 6 weeks of taking 1 capsule per day of either Longvida Curcumin, astaxanthin, or a placebo. A few side blood analysis will also be done. These measures are relevant to low level inflammation.

Conditions

Triglycerides

Keywords

Triglycerides; Antioxidants; Inflammation

Outcome Measures

Primary Outcomes (1)

• Trilgycerides

  Serum triglyceride readings (mg/dL)

  Pre and post 6 week intervention

Secondary Outcomes (2)

• Other blood lipids

  Before and after the 6 week intervention

• Inflammation markers

  Measures will be from blood samples taken before and after the 6 week intervention.

Study Arms (4)

Control

PLACEBO COMPARATOR

Subjects will be given 1 capsule per day of a small amount of cellulose

Other: Placebo Control

Regular dose curcumin

EXPERIMENTAL

Subjects will be given 1 capsule per day of a typical amount of Longvida curcumin (80 mg curcumin)

Dietary Supplement: Curcumin (Longvida™)

Low dose curcumin

EXPERIMENTAL

Subjects will be given 1 capsule per day of 40 mg curcumin which is half the typical amount of Longvida curcumin

Dietary Supplement: Half Dose Curcumin (Longvida™)

Astaxanthin

EXPERIMENTAL

Subjects will be given 1 capsule per day of a typical amount of astaxanthin (12 mg curcumin)

Dietary Supplement: Astaxanthin

Interventions

Curcumin (Longvida™) DIETARY_SUPPLEMENT

1 capsule per day at a usual curcumin dose for this particular product (80 mg curcumin)

Regular dose curcumin

Half Dose Curcumin (Longvida™) DIETARY_SUPPLEMENT

1 capsule per day at half the usual curcumin dose for this particular product (40 mg curcumin as the half dose)

Low dose curcumin

Astaxanthin DIETARY_SUPPLEMENT

1 capsule per day at a usual astaxanthin dose (12 mg)

Astaxanthin

Placebo Control OTHER

Subject will get 1 capsule per day of a small amount of cellulose

Control

Eligibility Criteria

• Age: 21 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Triglyceride reading of 140-250 mg/dL
• Age 21-59

You may not qualify if:

• Uncontrolled diabetes
• Hypothyroidism or other hormonal problems that have not stabilized
• Any liver diseases being actively treated
• Cancer
• Renal dialysis use
• Rheumatoid arthritis and related issues like lupus
• Inflammatory bowel disease
• Smoking
• Low blood pressure
• Having more than 5 alcoholic drinks per week
• Extreme obesity (BMI over 37)
• Pregnancy or lactation

Sponsors & Collaborators

• Medinutra LLC: lead

Study Sites (1)

Medinutra LLC

Dublin, Ohio, 43016, United States

RECRUITING

Related Publications (4)

• DiSilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79.

  PMID: 23013352 BACKGROUND

• Tikhonoff V, Casiglia E, Virdis A, Grassi G, Angeli F, Arca M, Barbagallo CM, Bombelli M, Cappelli F, Cianci R, Cicero AFG, Cirillo M, Cirillo P, Dell'oro R, D'elia L, Desideri G, Ferri C, Galletti F, Gesualdo L, Giannattasio C, Iaccarino G, Mallamaci F, Maloberti A, Masi S, Masulli M, Mazza A, Mengozzi A, Muiesan ML, Nazzaro P, Palatini P, Parati G, Pontremoli R, Quarti-Trevano F, Rattazzi M, Reboldi G, Rivasi G, Russo E, Salvetti M, Temporelli PL, Tocci G, Ungar A, Verdecchia P, Viazzi F, Volpe M, Borghi C. Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large Regional-Based Italian Database. J Am Heart Assoc. 2024 Feb 6;13(3):e030319. doi: 10.1161/JAHA.123.030319. Epub 2024 Jan 31.

  PMID: 38293920 BACKGROUND

• Kraaijenhof JM, Stroes ESG. Inflammatory Effects of Triglycerides: Relevant or Redundant? JACC Basic Transl Sci. 2023 May 22;8(5):476-478. doi: 10.1016/j.jacbts.2023.04.005. eCollection 2023 May.

  PMID: 37325399 BACKGROUND

• Yoshida H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H, Tada N. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis. 2010 Apr;209(2):520-3. doi: 10.1016/j.atherosclerosis.2009.10.012. Epub 2009 Oct 14.

  PMID: 19892350 BACKGROUND

MeSH Terms

Conditions

Inflammation

Interventions

Curcumin; astaxanthine

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diarylheptanoids; Heptanes; Alkanes; Hydrocarbons, Acyclic; Hydrocarbons; Organic Chemicals; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic

Study Officials

• Robert DiSilvestro, Ph.D.

  Medinutra LLC

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Robert DiSilvestro, Ph.D.

CONTACT

6143489375; nutritionstudy111@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2025
• First Posted: July 14, 2025
• Study Start: July 18, 2025
• Primary Completion: November 15, 2025
• Study Completion: December 1, 2025
• Last Updated: August 1, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)