Effect of Aerobic Exercise on Biomarkers in Depression

NCT07062783 | Recruiting

• 1 other identifier: DAE1
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.

Conditions

Major Depression

Keywords

Depression; Aerobic exercise; Oxidative stress; Growth factors

Outcome Measures

Primary Outcomes (2)

• Oxidative stress biomarkers

  It has been reported that the interaction between oxidative stress and the immune system is important, and that activated immune inflammatory pathways can trigger oxidative stress. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of oxidative stress (TAS, TOS, MDA, and F2-isoprostane) biomarkers, which play a role in the pathophysiology of depression.

  From enrollment to the end of treatment at 3 weeks

• Proinflmatuar sytokines

  It is believed that increased production of key proinflammatory cytokines such as interleukin tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1) and acute phase reactants plays an important role in the development of depression as a result of immune system involvement. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of inflammation (TNF-α, IL-6, IL-1) which play a role in the pathophysiology of depression.

  From enrollment to the end of treatment at 3 weeks

Study Arms (2)

Exercise Group

EXPERIMENTAL

Those included in the experimental group continued diaphragmatic breathing exercises every day for three weeks and walking exercises at least three days a week.

Other: Breathing exercise; Other: Aerobic Exercise

Control group

NO INTERVENTION

The control group continued their routine lives, and at the end of three weeks

Interventions

Breathing exercise OTHER

Volunteers participating in the study who were included in the experimental group performed breathing exercises every day for three weeks. They were taught to focus their attention on the hand on their abdominal area while breathing slowly through their nose and to increase abdominal movement while reducing chest movement. They were warned that during inspiration, as air filled their lungs, the hand on their abdomen should rise upward and the hand on their chest should not move excessively. Participants continued the training until they performed the exercise correctly. The diaphragmatic breathing exercise was performed for 10 minutes in the supine position during the first week, in the semi-sitting and/or sitting position during the second week, and in the standing position during the final week.

Exercise Group

Aerobic Exercise OTHER

The ratios determined as reference values for walking training in healthy adults (reference value for women = (2.11\*height) - (2.29\*body weight) - (5.78\*age) + 667 meters - reference value for men = (7.57\*height) - (1.76\*body weight) - (5.0 2\*age) - 309 meters) was performed at 80% intensity for at least 30 minutes on at least 3 days a week for 3 weeks. Aerobic exercise was considered for 3 weeks to facilitate adaptation to exercise and sustainability.

Exercise Group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Individuals who volunteer to participate in the study,
• Between the ages of 18 and 40,
• Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria

You may not qualify if:

• Individuals with chronic conditions accompanying depression,
• Those with walking difficulties
• Those with respiratory system disorders

Sponsors & Collaborators

• Kutahya Health Sciences University: lead
• Scientific Research Projects Coordination Unit: collaborator

Study Sites (1)

Kutahya Health Sciences University

Kütahya, Merkez, 43020, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Depressive Disorder, Major; Depression

Interventions

Breathing Exercises; Exercise

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Exercise Movement Techniques; Physical Therapy Modalities; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Hatice Solak, Assos. Prof

CONTACT

+90274 260 0043; hatice.solak@ksbu.edu.tr

Vedat Kurt, Assos. Prof.

CONTACT

+90 553 3813177; vedat.kurt@ksbu.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2025
• First Posted: July 14, 2025
• Study Start: August 1, 2024
• Primary Completion: August 31, 2025
• Study Completion: September 30, 2025
• Last Updated: September 5, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)