Antimicrobial Impact of Various RC Final Irrigation Activation Techniques

NCT07056127 | Not Yet Recruiting

• 1 other identifier: Irrigant activaion
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized clinical study aims to evaluate microbial reduction in root canals after using different final irrigation activation techniques including passive ultrasonic irrigation, XP-endo Finisher file and Laser ablation with Indocyanine green dye in comparison to manual dynamic activation.

Conditions

Root Canal Final Irrigation Activation Techniques

Keywords

Irrigant activation, ultrasonic, xp-endo finisher

Outcome Measures

Primary Outcomes (1)

• bacterial count

  24-48 hours

Study Arms (4)

manual dynamic agitation

ACTIVE COMPARATOR

Other: manual dynamic agitaion

ultrasonic activation

ACTIVE COMPARATOR

Other: ultrasonic activation

xp-endo finisher

ACTIVE COMPARATOR

Other: xp-endo finisher

laser

ACTIVE COMPARATOR

Other: laser

Interventions

manual dynamic agitaion OTHER

5 mL of 2.5% NaOCl solution will be activated with a well-fitting gutta-percha cone that will be placed to full working length and then will be moved in push-pull strokes of 2 mm amplitude at a frequency of 100 strokes in about 1 min

manual dynamic agitation

ultrasonic activation OTHER

5 mL of 5.25% NaOCl solution will be activated with PUI using a #20 endosonic file that will be driven by an ultrasonic device on medium power setting for 1 minute and inserted 1 mm short of the working length

ultrasonic activation

xp-endo finisher OTHER

5 mL of 5.25% NaOCl solution will be activated with XP-Endo Finisher which will be used in the canal for 1 minute at 800 rpm and 1 Ncm up to the working length and in slow up-and-down movements at 7-8mm length according to the manufacturer's recommendations

xp-endo finisher

laser OTHER

First, root canals will be filled with 0.5 mL of 0.05% ICG dye and left in place for 1 minute as preirradiation time. A #20 laser fiber will be inserted into the root canals to the working length. Then infrared diode laser with a wave length of 810 nm will be used to activate the dye for 30 seconds. For activation, circular movements will be performed along with the fiber removal movement . After the first activation, dye will be reintroduced, the laser fiber will be inserted again, and a new activation cycle of 30 seconds will be performed similarly to the previous one

laser

Eligibility Criteria

• Age: 15 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Vital/non vital single rooted teeth with single root canal with nearly the same apical diameter requiring root canal treatment.
• Teeth with sound periodontal apparatus.

You may not qualify if:

• Teeth with anatomic anomilies.
• Retreatment cases
• Pregnant patients

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Faculty of dentistry

Tanta, Egypt

Location

MeSH Terms

Interventions

Lasers

Intervention Hierarchy (Ancestors)

Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Central Study Contacts

Randa A Elsobky

CONTACT

+201019980198; dody.elsobky@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant teacher

Study Record Dates

• First Submitted: June 28, 2025
• First Posted: July 9, 2025
• Study Start: August 1, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: July 9, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)