Healthy Family Project: Tobacco Use and Smoke Exposure in Asian American Communities

NCT07049757 | Recruiting DMC

• 2 other identifiers: 24634NCI-2025-00206
• Study Type: interventional
• Target: 760
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates whether the Smokefree Family Living (SFL) intervention improves quit rates (smoking cessation) and exposure to tobacco contamination that stays in items such as, carpets, walls, and furniture, even after the smoke has cleared (third-hand smoke (THS)) among Chinese American smokers and their non-smoking household members. Smoking remains high among Chinese American males with limited ability to speak English. This causes the non-smoking household members to be exposed to THS, which contains many of the same harmful components as smoking and becomes more toxic as it ages. SFL is tailored for Chinese Americans and combines the contents of the Quit Smoking for a Healthy Family (QS) intervention with additional THS education and cleaning strategies. QS focuses on smoking cessation through educational sessions and support. THS education and cleaning strategies provide information on THS and how to clean the home for THS. SFL may help Chinese American smokers and their non-smoking household members learn about the importance of quitting and the dangers of THS, this may improve smoking cessation and reduce THS exposure

Conditions

Tobacco-Related Carcinoma; Smoking Cessation

Keywords

Third-hand Smoke

Outcome Measures

Primary Outcomes (1)

• Proportion of participants who have quit smoking at 6 months

  The smoking cessation rate is defined as the proportion of smokers who report quitting smoking, with biochemically verified 30-day point prevalent abstinence at the 6-month follow-up. Smoking rates will be reported by arm.

  6 months

Secondary Outcomes (2)

• Change in levels of tobacco smoke biomarkers for second-(SHS)hand smoke exposure

  Up to 6 months

• Proportion of participants who have quit smoking at 12 months

  Up to 12 months

Study Arms (3)

Intervention Development (Focus group + Interview)

EXPERIMENTAL

To achieve information gathering and preliminary adaptation design to prepare for the randomized clinical trial, focus groups and individual interviews with 24 participants (6 Chinese current smokers; 6 former smokers who have stopped smoking within the past 2 years; and 12 family/household members living with a current/former smoker) to review the newly developed or updated intervention materials. The Community Advisory Board (CAB) will also be involved in providing input.

Other: Focus Group

Arm I: Quit Smoking for a Healthy Family Group (QS)

ACTIVE COMPARATOR

Participants attend two QS educational sessions over 45-60 minutes one month apart and receive two follow-up phone calls over 15-30 minutes 1-2 weeks after each session over 6 weeks. Participants also receive a Healthy Family Action Plan as well as a smoking cessation resource guide and set goals on study. Participants then receive THS education and cleaning strategies at 6 months after the initial QS curriculum. Additionally, participants undergo urine sample collection throughout the study and non-smoking family/household members will wear a silicone wristband for 2 days at each assessment.

Other: Smoking cessation education; Behavioral: Survey Administration; Behavioral: Telephone-Based Intervention; Procedure: Urine Specimen Collection; Other: Silicone Wrist Band; Other: Interview

Arm II: Smokefree Family Living Group (SFL)

EXPERIMENTAL

Participants attend two QS educational sessions over 45-60 minutes one month apart and receive two follow-up phone calls over 15-30 minutes 1-2 weeks after each session over 6 weeks. During the second QS educational session, participants receive THS education and cleaning strategies. Participants also receive a Healthy Family Action Plan as well as a smoking cessation resource guide and set goals on study. Additionally, participants undergo urine sample collection throughout the study and non-smoking family/household members will wear a silicone wristband for 2 days at each assessment.

Other: Smoking cessation education; Behavioral: Survey Administration; Behavioral: Telephone-Based Intervention; Procedure: Urine Specimen Collection; Other: Silicone Wrist Band; Other: Interview

Interventions

Smoking cessation education OTHER

Quit Smoking for a Healthy Family (QS) and Smokefree Family Living (SFL) education sessions to promote smoking cessation and reduce tobacco smoke exposure.

Also known as: Education for Intervention, Intervention by Education, Intervention through Education

Arm I: Quit Smoking for a Healthy Family Group (QS); Arm II: Smokefree Family Living Group (SFL)

Survey Administration BEHAVIORAL

Administered for ancillary studies

Also known as: Questionnaires

Arm I: Quit Smoking for a Healthy Family Group (QS); Arm II: Smokefree Family Living Group (SFL)

Telephone-Based Intervention BEHAVIORAL

Participants will receive follow-up calls

Also known as: Telephone-Based Follow-up

Arm I: Quit Smoking for a Healthy Family Group (QS); Arm II: Smokefree Family Living Group (SFL)

Urine Specimen Collection PROCEDURE

Undergo urine sample collection at baseline

Also known as: Urine Sample

Arm I: Quit Smoking for a Healthy Family Group (QS); Arm II: Smokefree Family Living Group (SFL)

Silicone Wrist Band OTHER

Non-smoking family/household members will wear a silicone wristband for 2 days at each assessment for ancillary studies

Arm I: Quit Smoking for a Healthy Family Group (QS); Arm II: Smokefree Family Living Group (SFL)

Interview OTHER

Selected participants will take part in an interview for ancillary studies

Also known as: In-depth interview

Arm I: Quit Smoking for a Healthy Family Group (QS); Arm II: Smokefree Family Living Group (SFL)

Focus Group OTHER

Participants will review and comment on materials under development to be used in randomized clinical trial.

Intervention Development (Focus group + Interview)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All Participants (Lay Health Workers, Smokers, Family Participants, and Post-Trial Household Member Group Interview Participants):
• Must be 18 years of age or older.
• Must self-identify as Chinese or of Chinese descent (ethnic or cultural identification, not national origin).
• Must be able to understand in spoken Chinese (Cantonese and/or Mandarin) or English.
• Able to attend educational sessions in person or via video conferencing.
• Ability to understand and the willingness to sign a written informed consent document.
• Have a mobile phone that can receive Short Message Service (SMS) text messages, or an email address and a phone number where they can be reached by the study team.
• Lay Health Workers:
• Must have experience or interest in community outreach and education.
• Must demonstrate proficiency in language (Cantonese and/or Mandarin or English) sufficient to deliver study materials and interact with participants.
• Must be affiliated with the Chinese Community Health Resource Center (CCHRC) or recruited through community networks.
• Must agree to participate in training and intervention delivery activities as outlined in the study protocol.
• Smokers (Participants who are current smokers):
• Must have smoked within the past 30 days, either daily or occasionally.
• Must have a non-smoking household member.

You may not qualify if:

• Lay Health Workers, Smokers (Participants who are current smokers) and Family Participants (Non-smoking Family/household members):
• Currently participating in another smoking cessation program.
• Non-residents of California.
• Participants unwilling to provide follow-up contact for assessments at 6 and 12 months.
• Lay Health Workers:
• Lack of willingness or ability to complete training or deliver intervention sessions as required by the study protocol.
• Inability to maintain confidentiality and professionalism during interactions with study participants.
• Active participation in conflicting research studies or programs.

Sponsors & Collaborators

• Tobacco Related Disease Research Program: collaborator
• University of California, San Francisco: lead

Study Sites (1)

University of California, San Francisco

San Francisco, California, 94122, United States

RECRUITING

MeSH Terms

Conditions

Smoking Cessation

Interventions

Educational Status; Methods; Surveys and Questionnaires; Urine Specimen Collection; Interviews as Topic; Focus Groups

Condition Hierarchy (Ancestors)

Health Behavior; Behavior

Intervention Hierarchy (Ancestors)

Socioeconomic Factors; Population Characteristics; Investigative Techniques; Data Collection; Epidemiologic Methods; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Janice Tsoh, PhD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Edgar Yu

CONTACT

877-827-3222; edgar.yu@ucsf.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 25, 2025
• First Posted: July 3, 2025
• Study Start: June 11, 2025
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: March 24, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)