Comparison of Conventional and Non-Conventional CRF and Their Association With Acute Coronary Syndrome

NCT07049302 | Active Not Recruiting DMC

• 1 other identifier: MSAHSW/Batch-Fall23/911
• Study Type: observational
• Target: 222
• Locations: 1 country
• Sites: 1

Brief Summary

This research aims to compare conventional and non-conventional cardiovascular risk factors and their association with Acute Coronary Syndrome (ACS). Conventional risk factors such as hypertension, diabetes mellitus, dyslipidemia, smoking, and family history are well-established contributors to ACS. However, emerging non-conventional risk factors-including elevated inflammatory markers , homocysteine levels, lipoprotein(a), psychological stress, and lifestyle factors-are gaining attention for their potential role in cardiovascular events.

Conditions

Coronary Syndrome

Outcome Measures

Primary Outcomes (1)

• Structured Smoking Questionnaire

  A structured smoking questionnaire is a tool used to assess an individual's smoking habits, level of nicotine dependence, and potential motivations for smoking. These questionnaires typically include questions about cigarette consumption, brand preferences, smoking patterns, and the perceived effects of smoking. nterpretation: Higher scores indicate greater nicotine dependence. Scores: 0-2: Very low dependence 3-4: Low dependence 5: Moderate dependence 6-7: High dependence 8-10: Very high dependence

  12 Months

Study Arms (2)

Conventional Risk Factor Assessment

Combination Product: Conventional Risk Factor Assessment

Non-Conventional Risk Factor

Combination Product: Non-Conventional Risk Factor

Interventions

Conventional Risk Factor Assessment COMBINATION_PRODUCT

Participants in Group 1 will undergo evaluation for conventional cardiovascular risk factors associated with Acute Coronary Syndrome (ACS

Conventional Risk Factor Assessment

Non-Conventional Risk Factor COMBINATION_PRODUCT

Participants in Group 2 will be assessed for non-conventional cardiovascular risk factors associated with Acute Coronary Syndrome (ACS).

Non-Conventional Risk Factor

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will involve a cross-sectional analysis of ACS patients, examining the prevalence and impact of both types of risk factors. By assessing their relative contributions, the study aims to enhance understanding of ACS pathogenesis, identify at-risk populations more accurately, and support more comprehensive prevention strategies. The findings may help broaden clinical risk assessment tools and guide personalized interventions to reduce the incidence of ACS.

You may qualify if:

• Adult patients diagnosed with ACS.
• Patients providing informed consent for participation.

You may not qualify if:

• Patients with chronic heart diseases unrelated to ACS.
• Patients unable to provide consent due to critical illness.

Sponsors & Collaborators

• Superior University: lead

Study Sites (1)

Tertiary care hospital

Peshawar, Khyber Pakhtunkhwa, Pakistan

Location

MeSH Terms

Conditions

Angina, Unstable

Condition Hierarchy (Ancestors)

Angina Pectoris; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 25, 2025
• First Posted: July 3, 2025
• Study Start: March 17, 2025
• Primary Completion: September 1, 2025
• Study Completion: February 28, 2026
• Last Updated: July 3, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)