The Mauritius and Rodrigues Non-Communicable Disease (NCD) Study

NCT07048717 | Active Not Recruiting DMC

• 1 other identifier: 2023-07199-01
• Study Type: observational
• Target: 39,082
• Locations: 1 country
• Sites: 1

Brief Summary

Mauritius is located in the southern Indian Ocean with a population of 1.3 million in 2023. Mauritius is a multiethnic nation with 68% South Asian, 27% African (Creole), 3% Chinese and 2% Franco Mauritians. Seven population-based cross-sectional surveys using standardised protocols were conducted between 1987 and 2021). The participation rate has been over 85% in each survey. At each survey, participants were interviewed about living conditions, lifestyle and health, and anthropometry and blood pressure were measured. Biochemistry including lipids and an oral glucose tolerance test (OGTT) were performed Electrocardiograms (ECG) were recorded in participants aged 35 years and older. Previous participants were followed up in 2007 and 92% were successfully traced. Studies with identical methodology have been performed on the neighbouring island Rodrigues where the majority of the population are Creoles.

Conditions

Diabete Mellitus; Cardiovascular Disease Risk Factor; Ischemic Cardiovascular Disease; Hypertension; Obesity &Amp; Overweight

Keywords

Epidemiology; Cross-sectional studies; Prevalence; Incidence; Diabetes mellitus; Cardiovascular Disease

Outcome Measures

Primary Outcomes (1)

• Mortality

  According to household interviews, death certificates from central registers at Ministry of Health and Wellness. 1. Household interviews: "Is the participant alive? If dead, do you have a copy of the death certificate? When did the participant die?" 2. Central registers: Vital status, if dead, date and cause of death from death certificates" Combining 1 and 2 will give date and cause of death. Absolute numbers and mortality rates will be reported for all and in subgroups i.e. sex, age-strata, ethnicity.

  Up to 20 years from the baseline survey

Secondary Outcomes (4)

• Diabetes Mellitus

  Up to 20 years from the baseline survey

• Cardiovascular disease (CVD)

  Up to 20 years from the baseline survey

• Hypertension

  Up to 20 years from the baseline survey

• Obesity

  Up to 20 years from the baseline survey

Study Arms (2)

Randomly selected population-based subjects from the population (Mauritius)

Seven cross-sectional studies were performed between 1987 and 2021 on mainland Mauritius

Randomly selected population-based subjects from the population (Rodrigues)

In parallell, six cross-sectional studies were performed between 1992 and 2022 on Rodrigues

Eligibility Criteria

• Age: 25 Years - 74 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Random samples from the Mauritian (including Rodrigues) aged 25 to 74 years

You may qualify if:

• Men and women
• Randomly selected population-based samples (details see below)
• Not living in the study area
• Age outside the age-range
• In detail:
• In 2004, a new study was performed, with similar methodology. In 2009, nine index clusters were chosen with one randomly selected from each of the nine districts in Mauritius. Then, two neighbouring clusters were chosen surrounding the index cluster to form a "super cluster." From this super cluster, one in three households was randomly selected and one adult per household was invited to participate.5 The same methodology was used in 2015 and in 2021 with new randomly chosen clusters forming "super cluster" as in 2009. In addition, a random sample from the 1998 survey was invited for a resurvey in 2015.
• Participation rate has been over 85% in each survey. No sampling weights were used.
• Same methodology was used in Rodrigues.

Sponsors & Collaborators

• Umeå University: lead
• Ministry of Health and Wellness, Mauritius: collaborator
• University of Helsinki: collaborator
• Monash University: collaborator
• Imperial College London: collaborator
• Baker Heart and Diabetes Institute: collaborator

Study Sites (1)

Unknown Facility

Port Louis, Mauritius

Location

Related Publications (1)

• Soderberg S, Taki H, Kowlessur S, Shaw JE, Magliano DJ, Tamosiunas A, Alberti G, Zimmet P, Tuomilehto J. Trends in the prevalence of cardiovascular disease, defined as ECG abnormalities and/or self-reported events, in Mauritius between 1987 and 2021: analysis of data from seven large population-based surveys. BMJ Open. 2025 Jun 16;15(6):e087693. doi: 10.1136/bmjopen-2024-087693.

  PMID: 40523792 RESULT

Related Links

• Description of the Mauritian/Rodrigues NCD survey at Umeå University, Sweden

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma samples from the last surveys (2021 an 2022) are stored locally in Mauritius

MeSH Terms

Conditions

Diabetes Mellitus; Hypertension; Obesity; Overweight; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Vascular Diseases; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Paul Zimmet, Professor

  Monash University

  PRINCIPAL INVESTIGATOR

• George Alberti, Professor

  Imperial College, London, UK

  PRINCIPAL INVESTIGATOR

• Jaakko Tuomilehto, Professor

  Helsinki University, Helsinki, Finland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 20 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, consultant

Study Record Dates

• First Submitted: June 24, 2025
• First Posted: July 2, 2025
• Study Start: April 5, 1987
• Primary Completion: November 23, 2021
• Study Completion (Estimated): December 31, 2050
• Last Updated: July 17, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Available now
• Access Criteria: Reasonable request approved by senior researchers within the study group, plus obtained ethical approval.

Locations

MA (1)