Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid

NCT07046208 | Not Yet Recruiting DMC

• 2 other identifiers: 364599204000051744252664
• Study Type: interventional
• Target: 58
• Locations: 0 countries
• Sites: N/A

Brief Summary

Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.

Conditions

Long COVID; Heart Rate Variability (HRV); Cardiac Biomarkers; Inflammatory Biomarkers

Outcome Measures

Primary Outcomes (1)

• Autonomic Modulation

  cardiofrequency meter

  Before and afther the intervention 3 months.

Secondary Outcomes (1)

• Inflammation

  Before and the afther 3 months

Study Arms (1)

Rehabilitation for long covid

EXPERIMENTAL

Physioterapy protocol

Other: physiothreapy protocol

Interventions

physiothreapy protocol OTHER

Aerobic training (treadmill or exercise bike) for 15 minutes, anaerobic training at the weight training station, performing exercises for the upper limbs (bench press and front pull) and lower limbs (180º leg press and extension chair) with weight determined by the 1 Repetition Maximum (1RM) test, performing 3 sets of 12-15 repetitions (depending on the session) and respiratory muscle training using POWERbreathe (30-40% of the MIP performed in the manovacuometry test).

Rehabilitation for long covid

Eligibility Criteria

• Age: 20 Years - 59 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• both sexes
• aged 20 and 59 years
• clinical evaluation and undergoing clinical follow-up of Post COVID-19.
• least one persistent COVID-19-related symptom.

You may not qualify if:

• incomplete data.
• presence of a pacemaker
• use of antihypertensive drugs that alter HRV
• persistent pulmonary alterations
• persistent desaturation
• anaemia or presence of reinfection.

Sponsors & Collaborators

• Universidade do Estado do Pará: lead

Related Publications (1)

• Marques KC, Silva CC, Trindade SDS, Santos MCS, Rocha RSB, Vasconcelos PFDC, Quaresma JAS, Falcao LFM. Reduction of Cardiac Autonomic Modulation and Increased Sympathetic Activity by Heart Rate Variability in Patients With Long COVID. Front Cardiovasc Med. 2022 Apr 29;9:862001. doi: 10.3389/fcvm.2022.862001. eCollection 2022.

  PMID: 35571200 RESULT

MeSH Terms

Conditions

Post-Acute COVID-19 Syndrome

Condition Hierarchy (Ancestors)

COVID-19; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Luiz Magno Falcão, Research and coordinator

CONTACT

+5591982379488; fabiofalcao@uepa.br

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher

Study Record Dates

• First Submitted: June 29, 2025
• First Posted: July 1, 2025
• Study Start: August 11, 2025
• Primary Completion (Estimated): August 10, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: July 1, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share