Ultrasonographic Evaluation of the Ulnar Nerve in Individuals With and Without Generalized Joint Hypermobility

NCT07044986 | Not Yet Recruiting

• 1 other identifier: BeylikduzuStateH21
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will include 30 individuals diagnosed with Generalized Joint Hypermobility (GJH) based on the Beighton score and 30 healthy controls without GJH. Participants will undergo Tinel's test and the flexion-compression test. The presence of ulnar nerve-related symptoms such as pain and numbness will be recorded. Ultrasonographic evaluation of the ulnar nerve will be performed at the level of the medial epicondyle, as well as 2 cm proximal and distal to it. Cross-sectional area and diameter of the ulnar nerve will be measured at each site, repeated three times, and the average will be used. Additionally, ulnar nerve mobility during elbow flexion and extension will be assessed. The nerve will be classified as stable if it remains within the cubital tunnel, subluxated if it moves to the level of the epicondyle, and dislocated if it shifts anterior to the medial epicondyle.

Conditions

Hypermobility, Joint

Outcome Measures

Primary Outcomes (5)

• Ulnar nerve cross-sectional area (CSA) at the medial epicondyle

  CSA measurement provides insight into nerve thickening, which may indicate entrapment or irritation.

  0 day

• Ulnar nerve cross-sectional area (CSA) at the 2 cm proximal of medial epicondyle

  CSA measurement provides insight into nerve thickening, which may indicate entrapment or irritation.

  0 day

• Ulnar nerve cross-sectional area (CSA) at the 2 cm distal of medial epicondyle

  CSA measurement provides insight into nerve thickening, which may indicate entrapment or irritation.

  0 day

• Ulnar nerve diameter

  Ulnar nerve diameter with ultrasonography

  0 day

• Ulnar nerve mobility classification during elbow flexion (stable/subluxated/dislocated)

  Dynamic USG evaluation allows visualization of nerve movement and instability during joint motion.

  0 day

Secondary Outcomes (1)

• Presence of ulnar nerve-related symptoms:

  0 day

Study Arms (2)

hypermobility

patients with generalized joint hypermobility snyndrome

Other: no intervention

Control group

healthy control

Other: no intervention

Interventions

no intervention OTHER

no intervention

Control group; hypermobility

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

hypermobility and healthy controls

You may qualify if:

• Aged between 18 and 40 years
• A Beighton score of 4 or higher (indicative of Generalized Joint Hypermobility)
• Willingness to participate in the study

You may not qualify if:

• Being under 18 or over 40 years of age
• History of surgery or fracture in the elbow region
• Presence of active infection at the measurement site
• Presence of congenital anomaly in the upper extremity
• History of surgery involving neural structures in the upper extremity
• Presence of malignancy
• Pregnancy
• Presence of cognitive or psychiatric disorders

Sponsors & Collaborators

• Beylikduzu State Hospital: lead

Study Sites (1)

Beylikdüzü State Hospital

Istanbul, Beylikdüzü, 34147, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Joint Instability

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: June 22, 2025
• First Posted: July 1, 2025
• Study Start: July 1, 2025
• Primary Completion: August 1, 2025
• Study Completion: August 1, 2025
• Last Updated: July 1, 2025

Record last verified: 2025-06

Locations

TU (1)