Thumb Muscle Thickness and Strength in CMC Osteoarthritis

NCT06730698 | Completed

• 1 other identifier: BeylikduzuStateH11
• Study Type: observational
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

A total of 34 patients aged between 50-80 years, diagnosed with first carpometacarpal joint osteoarthritis based on hand radiographs taken within the last 3 months, will be included in the study from the Physical Therapy and Rehabilitation outpatient clinic. Sociodemographic data such as age, gender, height, weight, and BMI will be recorded. Based on their current radiographs, patients will be classified into two groups according to the Eaton-Littler classification: Stage 1-2 (early stage) and Stage 3-4 (advanced stage). Pain levels will be assessed using the Visual Analog Scale (VAS). Hand grip strength will be evaluated with a Jamar hand dynamometer, and pinch grip strength will be assessed with a Jamar pinch meter. The thicknesses of the abductor pollicis brevis, first dorsal interosseous, and opponens pollicis muscles will be measured using ultrasound. All assessments will be performed separately for the dominant and non-dominant hands.

Conditions

Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Thumb Muscle Thickness (Ultrasound)

  Measurement of the thickness of three thumb muscles-abductor pollicis brevis, first dorsal interosseous, and opponens pollicis-using ultrasonography. These measurements will help determine muscle atrophy or hypertrophy related to disease severity and stage

  0 day

Secondary Outcomes (3)

• Grip Strength

  0 day

• Pinch Strength

  0 day

• Pain Level (VAS)

  0 day

Study Arms (2)

Early stage osteoarthritis

Early stage osteoarthritis according to Eaton-Litter classification (stage 1 and 2)

Other: No intervention

Advanced stage osteoarthritis

Advanced stage osteoarthritis according to Eaton-Litter classification (stage 3 and 4)

Other: No intervention

Interventions

No intervention OTHER

No intervention

Advanced stage osteoarthritis; Early stage osteoarthritis

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population includes patients aged 50-80 years with first carpometacarpal joint osteoarthritis, classified into early and advanced stages based on radiographs, excluding those with confounding medical or cognitive conditions.

You may qualify if:

• Patients aged 50-80 years.
• Diagnosed with first carpometacarpal joint osteoarthritis.
• Presence of a hand radiograph taken within the last 3 months.
• Volunteered to participate in the study.

You may not qualify if:

• Refusal to participate in the study.
• Use of medications that may suppress osteoarthritis flares.
• Presence of rheumatologic diseases causing peripheral joint involvement.
• History of fractures or surgeries involving the first carpometacarpal joint.
• Presence of psychiatric disorders.
• Presence of cognitive impairments that could hinder understanding or performance of study-related tasks.

Sponsors & Collaborators

• Beylikduzu State Hospital: lead

Study Sites (1)

Beylikdüzü State Hospital

Istanbul, Beylikdüzü, 34147, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Büşra Şirin Ahısha

  Beylikdüzü State Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: December 9, 2024
• First Posted: December 12, 2024
• Study Start: December 10, 2024
• Primary Completion: January 20, 2025
• Study Completion: January 20, 2025
• Last Updated: March 26, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)