Thrombus Analysis of Ischemic Stroke

NCT07043413 | Recruiting

• 1 other identifier: TAOIST
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with acute ischemic stroke who have undergone endovascular thrombectomy will be eligible to be included, and thrombus will be collected after obtaining informed consent. Enrolled patients will receive a comprehensive diagnostic evaluation and the best medical treatment according to recent stroke management guidelines. The mechanism of the stroke will be classified into atherosclerotic, cardiac embolism, others and unknown causes based on diagnostic workup. Patients will be monitored in an outpatient clinic for vascular events including stroke recurrence, death, and bleeding events, which will continue for up to two years after the initial stroke event. Thrombus information related to RNA expression patterns and histological characteristics will be analyzed to classify the stroke mechanism and predict future vascular events after the initial stroke.

Conditions

Cerebral Infarction

Keywords

cerebral infarction; thrombus; stroke mechanism; prognosis

Outcome Measures

Primary Outcomes (1)

• Vascular events

  major vascular events after endovascular thrombectomy, including stroke, myocardial infarction, and vascular death

  two years after initial stroke

Secondary Outcomes (1)

• Thromboembolic events

  two years after initial stroke

Other Outcomes (1)

• overall mortality

  two years after initial stroke

Interventions

thrombus analysis DIAGNOSTIC_TEST

Detailed expression pattern of RNA and histological characteristics will be investigated.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with acute ischemic stroke who had undergone endovascular thrombectomy and agreed to participate to the study

You may qualify if:

• patients with acute ischemic stroke who had undergone endovascular thrombectomy

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, Jong-ro Gu, 03080, South Korea

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

human thrombus obtained after endovascular thrombectomy

MeSH Terms

Conditions

Cerebral Infarction; Thrombosis

Condition Hierarchy (Ancestors)

Brain Infarction; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Vascular Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Embolism and Thrombosis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 20, 2025
• First Posted: June 29, 2025
• Study Start: January 25, 2022
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2029
• Last Updated: June 29, 2025

Record last verified: 2025-06

Locations

KR (1)