Early Neurological Deterioration in Patients With Acute Ischemic Stroke
ENDAIS
Explore the Causes and Predictors of Early Neurological Deterioration Occurred in Patients With Acute Ischemic Stroke
1 other identifier
observational
1,200
1 country
1
Brief Summary
This study set out to explore the risk factors of early neurological deterioration (END) occurred in patients with acute ischemic stroke and to investigate the corresponding predictors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 26, 2018
CompletedFirst Posted
Study publicly available on registry
October 12, 2018
CompletedStudy Start
First participant enrolled
November 20, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 25, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
January 30, 2019
CompletedJanuary 31, 2019
January 1, 2019
2 months
June 26, 2018
January 30, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
National Institutes of Health Stroke Scale
National Institutes of Health Stroke Scale (NIHSS) can assess the severity of stroke. The total score of NIHSS ranges from 0 to 42, with higher scores indicating better neurological function.
7 days
Canadian Neurological Scale
Canadian Neurological Scale (CNS) can assess the severity of stroke as well. The total score of CNS ranges from 0 to 10, with higher scores indicating worse neurological function.
7 days
Secondary Outcomes (2)
Blood parameters
7days
Neuroimaging data
7days
Study Arms (2)
END group
The patients in this group had an elevation of ≥ 2 points in the National Institute of Health Stroke Scale (NIHSS) within 7 days of stroke onset.
non-END group
The patients in this group had a slight increase of \< 2 points or a decrease in NIHSS within 7 days of stroke onset.
Eligibility Criteria
Patients admitted to First Affiliated Hospital of Nangjing Medical University from January 2015 to April 2018 were collected retrospectively.
You may qualify if:
- Subjects with acute ischemic stroke
- Subjects with detailed progress notes
You may not qualify if:
- Subjects with thrombolysis therapy
- Subjects with transient ischemia attach
- Subjects complicated with seriously underlying diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
First Affiliated Hospital of Nanjing Medical University
Nanjing, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 26, 2018
First Posted
October 12, 2018
Study Start
November 20, 2018
Primary Completion
January 25, 2019
Study Completion
January 30, 2019
Last Updated
January 31, 2019
Record last verified: 2019-01