A Mechanistic Study on How Humid and Hot Environment Promotes Urinary Tract Stone Formation Through Influencing Gut Microbiota and Tryptophan Metabolism
Sponsor study identifier
observational
270
0 countries
N/A
Study Start
September 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 20, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 21, 2025
Actual (reported)June 29, 2025
Actual (reported)September 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
November 20, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Gut microbiota differences
Comparison of gut microbiota composition between the case and control groups, particularly the relative abundance of Lactobacillus salivarius. Unit of Measure: Relative abundance (unitless proportion)
3 months postoperatively
Serum indole-3-carboxylic acid (ICA) concentration and Serum kynurenine (Kyn) concentration
Comparison of serum ICA (indole-3-carboxylic acid) and Kyn (kynurenine) levels between the case and control groups. Unit of Measure: ng/mL.
3 months postoperatively
Kynurenine to indole-3-carboxylic acid ratio (Kyn/ICA)
3 months postoperatively
Spearman correlation coefficient between Lactobacillus salivarius abundance and serum ICA concentration
3 months postoperatively
Gut microbiota α-diversity
3 months postoperatively
Gut microbiota β-diversity
3 months postoperatively
Relative abundance of Lactobacillus salivarius
3 months postoperatively
Patients diagnosed with kidney stones via imaging examinations (ultrasound, CT, or urography) were recruited from both outpatient clinics and inpatient departments of the Urology Department at our hospital.
1. Recruit healthy volunteers confirmed by imaging examinations to be free of kidney stones from our hospital's Physical Examination Center. 2. Recruit patients with no history of kidney diseases from other departments of our hospital (e.g., Department of Orthopedics, Department of General Surgery). 3. Recruit healthy volunteers through community outreach, confirmed by ultrasound examination to be free of kidney stones.
Case group: Patients diagnosed with kidney stones Control group: Healthy volunteers without kidney stones
Shao Yi
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
First Submitted
May 21, 2025
First Posted
June 29, 2025
Study Start
September 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 20, 2026
Study of Ketorolac Versus Opioid for Pain After Endoscopy
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
January 21, 2026
Record last verified: 2026-01
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