Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens

NCT07043166 | Recruiting DMC

• 1 other identifier: STONE
• Study Type: observational
• Target: 4,094
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017. The secondary aim is to compare metabolic risk factors, metabolic disturbances, and clinically relevant metabolic outcomes between the follow-up period and the baseline assessment. The exploratory goal is to examine the relationships between changes in risk factors and clinical outcomes in the participants. The study is planned to begin in May 2025 and will finalize the data collection for the entire population by June 2026. During this time, participants will be categorized based on CKM staging. The follow-up phase will continue until 2035.

Conditions

Metabolic Syndrome; Diabetes; Obesity and Overweight; Hypertension; Dyslipidemia; Thyroid Diseases; Bone Metabolism Disorder; Chronic Kidney Disease(CKD); Cardiovascular Diseases (CVD); Cardiovascular-kidney-metabolic Syndrome

Keywords

Cardiovascular-Kidney-Metabolic Syndrome; metabolic disorders; screening; risk factor; evaluation; prediction

Outcome Measures

Primary Outcomes (1)

• Number of Participants Who developed cardiovascular diseases.

  The diagnosis of cardiovascular diseases should be made according to the outcomes of carotid ultrasound and cardiac biomarkers.

  Through study completion, an average of 10 year

Secondary Outcomes (1)

• Number of Participants Who developed metabolic disorders.

  Through study completion, an average of 10 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 4,094 residents were drawn from 10 communities in Shanghai, with baseline multidimensional data collected."

You may qualify if:

• The 4,094 residents of Shanghai communities who have been enrolled in the STONE cohort.
• Individuals who completed the baseline questionnaire survey, physical examination, and related clinical tests between 2016 and 2017, with complete data records.
• Willingness to participate in this follow-up study and provision of informed consent.

You may not qualify if:

• Participants who have moved away from their original community and have been living elsewhere for more than two years.
• Participants whose contact information has changed or become invalid, resulting in loss of contact (those who remain uncontactable after three attempts to reach out).

Sponsors & Collaborators

• Shanghai Changzheng Hospital: lead

Study Sites (1)

Shanghai Changzheng Hospital

Shanghai, Shanghai Municipality, 200003, China

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Venous blood samples will be collected at every visit

MeSH Terms

Conditions

Metabolic Syndrome; Diabetes Mellitus; Obesity; Overweight; Hypertension; Dyslipidemias; Thyroid Diseases; Bone Diseases, Metabolic; Renal Insufficiency, Chronic; Cardiovascular Diseases; Metabolic Diseases

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Lipid Metabolism Disorders; Bone Diseases; Musculoskeletal Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes

Study Officials

• tuo Li, Prof.

  Shanghai Changzheng Hospital

  STUDY DIRECTOR

Central Study Contacts

tuo Tuo Li, Doctor

CONTACT

86-13918507887; dr.lituo@smmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Director

Study Record Dates

• First Submitted: June 14, 2025
• First Posted: June 29, 2025
• Study Start: July 1, 2025
• Primary Completion (Estimated): May 30, 2035
• Study Completion (Estimated): December 31, 2035
• Last Updated: September 8, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)