The Influence of Virtual Reality on Blood Parameters

NCT07042178 | Completed

• 2 other identifiers: 25U-0212NL-009813
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to learn what the impact of exposure to virtual reality content is on the levels of stress-related blood values in healthy volunteers. The main question it aims to answer is:

• To compare the levels of stress-related biomarkers before and after relaxing VR-content (Relax Visit);
• To compare the levels of stress-related biomarkers before and after stress-inducing VR-content (Rollercoaster Visit). Researchers will compare the Relax and Rollercoaster Visit to see if there is a relationship between the relaxing and stress-inducing VR content on stress-related blood values. Participants will be asked to watch relaxing or stress-inducing VR content for approximately five minutes. Blood will be withdrawn before and after intervention. After 3-5 weeks the study visit will be repeated using the other VR content.

Conditions

Virtual Reality Pain Distraction; Endocrinology; Haematology

Keywords

Virtual reality; Stress-related biomarkers; Rollercoaster

Outcome Measures

Primary Outcomes (21)

• The effect of relaxing VR content on von Willebrand ristocetin co-factor activity

  The difference between von Willebrand ristocetin co-factor activity before and after relaxing VR content (beach meditation video) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR content on von Willebrand ristocetin co-factor activity

  The difference between von Willebrand ristocetin co-factor activity before and after stress-inducing VR content (rollercoaster ride) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on von Willebrand ristocetin co-factor activity

  The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for von Willebrand ristocetin co-factor activity is assessed.

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

• The effect of relaxing VR content on FVIII activity

  The difference between FVIII activity before and after relaxing VR content (beach meditation video) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR content on FVIII activity

  The difference between FVIII activity before and after stress-inducing VR content (rollercoaster ride) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on FVIII activity

  The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for FVIII activity is assessed.

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

• The effect of relaxing VR content on copeptin

  The difference between copeptin before and after relaxing VR content (beach meditation video) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR content on copeptin

  The difference between copeptin before and after stress-inducing VR content (rollercoaster ride) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on copeptin

  The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for copeptin is assessed.

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

• The effect of relaxing VR content on prolactin

  The difference between prolactin before and after relaxing VR content (beach meditation video) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR content on prolactin

  The difference between prolactin before and after stress-inducing VR content (rollercoaster ride) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on prolactin

  The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for prolactin is assessed.

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

• The effect of relaxing VR content on thyroid stimulating hormone (TSH)

  The difference between TSH before and after relaxing VR content (beach meditation video) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR content on TSH

  The difference between TSH before and after stress-inducing VR content (rollercoaster ride) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on TSH

  The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for TSH is assessed.

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

• The effect of relaxing VR content on cortisol

  The difference between cortisol before and after relaxing VR content (beach meditation video) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR content on cortisol

  The difference between cortisol before and after stress-inducing VR content (rollercoaster ride) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on cortisol

  The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for cortisol is assessed.

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

• The effect of relaxing VR content on glucose

  The difference between glucose before and after relaxing VR content (beach meditation video) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR content on glucose

  The difference between glucose before and after stress-inducing VR content (rollercoaster ride) is measured.

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on glucose

  The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for glucose is assessed.

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

Secondary Outcomes (14)

• The effect of relaxing VR-content on blood pressure

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR-content on blood pressure

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

• The correlation between relaxing and stress-inducing VR content on blood pressure

  From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)

• The effect of relaxing VR-content on temperature

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)

• The effect of stress-inducing VR-content on temperature

  From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)

Study Arms (2)

Arm A

EXPERIMENTAL

Arm A receives the Relax visit first and 3-5 weeks later the Rollercoaster Visit.

Other: Meditation video at the beach; Other: Rollercoaster video

Arm B

EXPERIMENTAL

Arm B receives the Rollercoaster Visit first and 3-5 weeks later the Relax Visit.

Other: Meditation video at the beach; Other: Rollercoaster video

Interventions

Meditation video at the beach OTHER

A virtual reality video consisting of a 5 minute meditation video at te beach.

Arm A; Arm B

Rollercoaster video OTHER

A virtual reality video consisting of a five minute rollercoaster ride.

Arm A; Arm B

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 45 years old;
• Willing and able to provide written informed consent.

You may not qualify if:

• A history of motion- or cybersickness;
• Fear of needles;
• Any of the following haematological disorders:
• Congenital or acquired haemophilia A;
• Von Willebrand Disease.
• Any of the following endocrinological disorders:
• Thyroid disorders (e.g. hypo/hyperthyroidism);
• Cushing syndrome;
• Adrenal insufficiency;
• Diabetes mellitus type 1 or 2;
• Central or nephrogenic AVP deficiency.
• A confirmed cardiac disorder;
• All types of epilepsy;
• Every form of medication, except for intermittent use of pain killers but not in the last week (e.g. paracetamol) and an intra-uterine device with or without contraceptive;
• Pregnancy.

Sponsors & Collaborators

• Van Creveldkliniek: lead

Study Sites (1)

University Medical Centre Utrecht

Utrecht, 3584CX, Netherlands

Location

Study Officials

• Corien L. Eckhardt, MD PhD

  UMC Utrecht

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Center for Benign Hematology, Thrombosis and Haemostasis

Study Record Dates

• First Submitted: June 11, 2025
• First Posted: June 27, 2025
• Study Start: August 27, 2025
• Primary Completion: February 20, 2026
• Study Completion: February 20, 2026
• Last Updated: April 29, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: CSR

Locations

NL (1)