Empowering Knowledge, Self-Testing & Resilience Through Innovative Methods for HIV

NCT07039682 | Not Yet Recruiting DMC

• 2 other identifiers: 63/UN27.06.11/KEP/EC/2025400422-409
• Study Type: interventional
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to learn whether a digital tool can help improve HIV knowledge, self-awareness, and testing among adolescents in Yogyakarta, Indonesia. The tool includes online HIV education, a self-assessment for HIV risk, and access to trained peer educators for support. The study will also explore how comfortable and willing adolescents are to use this kind of digital health service. The main questions the study aims to answer are:

• Can this digital tool help adolescents better understand HIV and their personal risk?
• Will more adolescents be willing to get tested for HIV after using the tool?
• What factors affect whether adolescents accept and use digital HIV services? Researchers will compare two groups of high school students:
• One group will use the digital tool for 6 weeks
• The other group will receive standard HIV education (not through the tool) Participants will:
• Answer surveys before and after the 6-week period
• Learn about HIV through videos and interactive content
• Use the tool to assess their personal HIV risk
• Receive support from trained peer educators (online) The researchers hope this study will lead to new ways of using technology to improve HIV prevention and testing for young people.

Conditions

Human Immunodeficiency Virus (HIV) Infection; HIV Prevention; Adolescent Health; Digital Education Interventions; Digital Health Intervention; Health Education; HIV Stigma

Keywords

hiv prevention; adolescent health; health education; digital intervention

Outcome Measures

Primary Outcomes (1)

• HIV Testing Uptake Among Adolescents Using a Digital Self-Screening and Education Platform

  Proportion of adolescents aged 15-17 who undergo voluntary HIV testing following engagement with the EKSTRIM digital platform, which includes audiovisual education, risk self-assessment, and online counseling. This outcome measures the effectiveness of the intervention in increasing HIV testing behavior compared to baseline where no participants had ever been tested, despite prior exposure to HIV-related information. Data will be collected through platform records and follow-up surveys to confirm testing uptake and linkage to services.

  Within 3 months after initial platform engagement

Secondary Outcomes (1)

• Change in HIV Knowledge and Self Awareness Among Adolescents

  From baseline to 4 weeks after initial platform use.

Study Arms (2)

Digital HIV Education and Self-Screening (EKSTRIM Model)

EXPERIMENTAL

Participants in this arm will receive access to the EKSTRIM platform, a web-based digital tool designed for adolescents. The platform includes interactive educational content on HIV prevention, a self-assessment screening tool to evaluate individual HIV risk, and online peer educator support. The intervention will be implemented over a 6-week period. Participants will be encouraged to use the platform independently, with monitoring of access logs and engagement levels.

Device: Digital HIV Education and Self-Screening (EKSTRIM Model)

Standard/Usual HIV Education Program

NO INTERVENTION

Participants in this arm will receive standard HIV-related education as provided through the school health program. This includes printed materials and classroom-based health education without access to digital tools or peer educator interaction. This group will serve as the comparison to evaluate the added impact of the digital EKSTRIM intervention.

Interventions

Digital HIV Education and Self-Screening (EKSTRIM Model) DEVICE

Participants in this arm will receive access to the EKSTRIM platform, a web-based digital tool designed for adolescents. The platform includes interactive educational content on HIV prevention, a self-assessment screening tool to evaluate individual HIV risk, and online peer educator support. The intervention will be implemented over a 6-week period. Participants will be encouraged to use the platform independently, with monitoring of access logs and engagement levels.

Digital HIV Education and Self-Screening (EKSTRIM Model)

Eligibility Criteria

• Age: 15 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Adolescents aged 15-17 years
• Reside or attend school in the Yogyakarta area
• Currently enrolled in one of the participating high schools
• Able to read and understand Bahasa Indonesia
• Own or have regular access to a smartphone or digital device with internet connectivity
• Provide informed assent to participate in the study
• Have obtained written parental or guardian consent

You may not qualify if:

• Adolescents outside the 15-17 age range
• Unable to access digital devices or internet independently
• Previously diagnosed with HIV (as this study targets prevention and self-screening among untested adolescents)
• Unwilling or unable to provide informed assent or whose parents/guardians do not provide consent
• Currently participating in another HIV-related intervention study

Sponsors & Collaborators

• Universitas Sebelas Maret: lead

Study Sites (1)

Universitas Sebelas Maret

Surakarta, Central Java, 57126, Indonesia

Location

Related Publications (10)

• Tang L, Wang J. Exploring the Relationship between Health Information Literacy and Health Behaviors of the Elderly. Iran J Public Health. 2023 Jul;52(7):1439-1446. doi: 10.18502/ijph.v52i7.13245.

  PMID: 37593515 BACKGROUND

• Felsen UR, Tlamsa A, Moir L, Shukla S, Thompson D, Weiss JM, Heo M, Litwin AH. Comparing Routine HIV and Hepatitis C Virus Screening to Estimate the Effect of Required Consent on HIV Screening Rates Among Hospitalized Patients. Public Health Rep. 2022 Jan-Feb;137(1):102-109. doi: 10.1177/0033354921999170. Epub 2021 Mar 5.

  PMID: 33673778 BACKGROUND

• Xiong S, Lu H, Peoples N, Duman EK, Najarro A, Ni Z, Gong E, Yin R, Ostbye T, Palileo-Villanueva LM, Doma R, Kafle S, Tian M, Yan LL. Digital health interventions for non-communicable disease management in primary health care in low-and middle-income countries. NPJ Digit Med. 2023 Feb 1;6(1):12. doi: 10.1038/s41746-023-00764-4.

  PMID: 36725977 BACKGROUND

• Jenkins CL, Imran S, Mahmood A, Bradbury K, Murray E, Stevenson F, Hamilton FL. Digital Health Intervention Design and Deployment for Engaging Demographic Groups Likely to Be Affected by the Digital Divide: Protocol for a Systematic Scoping Review. JMIR Res Protoc. 2022 Mar 18;11(3):e32538. doi: 10.2196/32538.

  PMID: 35302946 BACKGROUND

• Cheng AL, Leo AJ, Calfee RP, Dy CJ, Armbrecht MA, Abraham J. Multi-stakeholder perspectives regarding preferred modalities for mental health intervention delivered in the orthopedic clinic: a qualitative analysis. BMC Psychiatry. 2023 May 19;23(1):347. doi: 10.1186/s12888-023-04868-9.

  PMID: 37208668 BACKGROUND

• Ibrahim MS, Mohamed Yusoff H, Abu Bakar YI, Thwe Aung MM, Abas MI, Ramli RA. Digital health for quality healthcare: A systematic mapping of review studies. Digit Health. 2022 Mar 18;8:20552076221085810. doi: 10.1177/20552076221085810. eCollection 2022 Jan-Dec.

  PMID: 35340904 BACKGROUND

• Ninsiima M, Nyabigambo A, Kagaayi J. Acceptability of integration of cervical cancer screening into routine HIV care, associated factors and perceptions among HIV-infected women: a mixed methods study at Mbarara Regional Referral Hospital, Uganda. BMC Health Serv Res. 2023 Apr 3;23(1):333. doi: 10.1186/s12913-023-09326-6.

  PMID: 37013535 BACKGROUND

• Putri WCWS, Ulandari LPS, Valerie IC, Prabowo BR, Hardiawan D, Sihaloho ED, Relaksana R, Wardhani BDK, Harjana NPA, Nugrahani NW, Siregar AYM, Januraga PP. Costs and scale-up costs of community-based Oral HIV Self-Testing for female sex workers and men who have sex with men in Jakarta and Bali, Indonesia. BMC Health Serv Res. 2024 Jan 22;24(1):114. doi: 10.1186/s12913-024-10577-0.

  PMID: 38254186 BACKGROUND

• Johnston LG, Soe P, Widihastuti AS, Camellia A, Putri TA, Rakhmat FF, Nurwandani RA, Prabhu SM, Sulaiman N, Pronyk PM. Alarmingly High HIV Prevalence Among Adolescent and Young Men Who have Sex with Men (MSM) in Urban Indonesia. AIDS Behav. 2021 Nov;25(11):3687-3694. doi: 10.1007/s10461-021-03347-0. Epub 2021 Jun 18.

  PMID: 34143341 BACKGROUND

• Yoon J, Lee M, Ahn JS, Oh D, Shin SY, Chang YJ, Cho J. Development and Validation of Digital Health Technology Literacy Assessment Questionnaire. J Med Syst. 2022 Jan 24;46(2):13. doi: 10.1007/s10916-022-01800-8.

  PMID: 35072816 BACKGROUND

Related Links

• EKSTRIM study protocol

MeSH Terms

Conditions

Acquired Immunodeficiency Syndrome; Health Education

Condition Hierarchy (Ancestors)

HIV Infections; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Slow Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Adherence Interventions; Medication Adherence; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Officials

• Rizka Ayu Setyani, Doctoral/PhD

  Universitas Sebelas Maret

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rizka Ayu Setyani, Doctoral/PhD

CONTACT

+6285647026667; setyanirizkaayu@gmail.com

Fika Lilik Indrawati, Master

CONTACT

+6282137528016; fika.lilik.indrawati@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: This study uses a double-blind design in which both participants and investigators are unaware of group allocation (intervention or control). The outcomes assessor is also blinded to minimize assessment bias. Only the data analyst, independent from the implementation team, will have access to the allocation code after data collection is complete.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Universitas Sebelas Maret

Study Record Dates

• First Submitted: June 18, 2025
• First Posted: June 26, 2025
• Study Start: July 31, 2025
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: June 26, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)