Evaluation of Stone Composition in Surgical Kidney Stone Patients in Vietnam

NCT07038954 | Completed

• 2 other identifiers: BDH-STONE-202322441
• Study Type: observational
• Target: 222
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective observational study conducted at Binh Dan Hospital, Ho Chi Minh City, Vietnam, from July to December 2023. The study aims to analyze the composition of kidney stones in patients undergoing surgical interventions such as percutaneous nephrolithotomy (PCNL), ureteroscopic lithotripsy, laparoscopic ureterolithotomy, or open surgery. Stone fragments collected during the procedures were analyzed using X-ray diffraction (XRD) and infrared spectroscopy (IR). The primary goal of this study is to identify the types and distribution of kidney stone compositions in a Vietnamese surgical cohort and compare them with global patterns. Findings from this study are expected to provide insights into age- and gender-related differences in stone composition, and contribute to improved prevention strategies for recurrent urolithiasis. The study was approved by the Ethics Committee of the University of Medicine and Pharmacy at Ho Chi Minh City. All participants provided written informed consent.

Conditions

Kidney Stones; Urolithiasis; Nephrolithiasis

Keywords

Kidney stone composition; Percutaneous nephrolithotomy; Stone analysis; Infrared spectroscopy; Calcium oxalate; Vietnam; Binh Dan Hospital; Surgical stone treatment; Recurrent kidney stones

Outcome Measures

Primary Outcomes (1)

• Proportion of stone types in surgically treated kidney stone patients

  Determination of the proportion of each major stone type (calcium oxalate, phosphate, uric acid, struvite, and cystine) using X-ray diffraction (XRD) and infrared spectroscopy (IR).

  Within 1 month after surgical stone removal

Study Arms (1)

Surgically Treated Kidney Stone Patients

This cohort includes patients aged 15 years and older who underwent surgical treatment for kidney or ureteral stones at Binh Dan Hospital between July and December 2023. Surgical methods included percutaneous nephrolithotomy (PCNL), semirigid ureteroscopic lithotripsy, laparoscopic ureterolithotomy, and open surgery. Retrieved stone fragments were analyzed using X-ray diffraction (XRD) and infrared spectroscopy (IR) to determine stone composition. No experimental intervention was applied.

Other: Stone Composition Analysis

Interventions

Stone Composition Analysis OTHER

This intervention involves the compositional analysis of kidney stone fragments retrieved during surgical procedures. The stone samples are analyzed using X-ray diffraction (XRD) and infrared spectroscopy (IR) to determine their crystal composition. This is a non-invasive, laboratory-based diagnostic procedure. No drug, device, or therapeutic intervention was administered to participants as part of this observational study.

Surgically Treated Kidney Stone Patients

Eligibility Criteria

• Age: 15 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with kidney stones who underwent surgical treatment at Binh Dan Hospital from July to December 2023 and consented to stone analysis.

You may qualify if:

• Patients aged 15 years and older.
• Diagnosed with kidney or ureteral stones requiring surgical intervention.
• Underwent PCNL, URS, laparoscopic ureterolithotomy, or open stone surgery.
• Provided written informed consent.

You may not qualify if:

• Patients with missing or unsuitable stone samples.
• Patients with incomplete clinical data.
• Patients with contraindications to surgery.
• Pregnant women

Sponsors & Collaborators

• Binh Dan Hospital: lead
• Department of Science and Technology of Ho Chi Minh City: collaborator

Study Sites (1)

Binh Dan Hospital

Ho Chi Minh City, Ho Chi Minh, 700000, Vietnam

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Kidney stone fragments collected during surgical procedures, including percutaneous nephrolithotomy (PCNL), ureteroscopic lithotripsy, laparoscopic ureterolithotomy, and open stone removal. Samples were retained for compositional analysis using X-ray diffraction (XRD) and infrared spectroscopy (IR). No blood, tissue, or DNA-based samples were collected or retained.

MeSH Terms

Conditions

Kidney Calculi; Urolithiasis; Nephrolithiasis

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 5, 2025
• First Posted: June 26, 2025
• Study Start: July 1, 2023
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: June 26, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

VN (1)