Impact of Pre- and Post-operative Serum Metabolome Dynamics in Colorectal Resection Outcomes

NCT07035262 | Active Not Recruiting DMC

• 1 other identifier: 2025-364-01
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to systematically analyze the dynamic pattern of preoperative and postoperative serum metabolites in colorectal cancer patients through metabolomics technology, and to screen the key metabolites with statistical differences and explore their correlation with surgical interventions by combining the baseline characteristics of the patients with the perioperative clinical data; to further reveal the impact of surgery on the body's metabolic remodeling pattern, and to explore the potential biomarkers and regulatory pathways, providing a theoretical basis for elucidating the metabolic mechanism. Investigaters will further reveal the impact of surgery on metabolic remodeling, explore potential biomarkers and regulatory pathways, provide theoretical basis for elucidating the metabolic mechanism, and evaluate its clinical translational value (e.g., postoperative monitoring, targeted intervention, etc.), so as to lay the foundation for the subsequent basic research and precise treatment strategies.

Conditions

Colo-rectal Cancer

Keywords

colorectal cancer; postoperative complication; surgery; metabolites

Outcome Measures

Primary Outcomes (1)

• postoperative complications

  Postoperative complications occurring within two months after surgery.

  From the first day of surgery to two months after surgery

Study Arms (1)

the colorectal cancer group

patients diagnosed with colorectal cancer

Other: serum metabolites

Interventions

serum metabolites OTHER

serum metabolites before and after colorectal cancer surgery

the colorectal cancer group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients diagnosed with colorectal cancer

You may qualify if:

• Previous consent to participate;
• Blood drawn and serum samples extracted and preserved both preoperatively and postoperatively;
• Successful detection of metabolomics profiles from serum samples;
• Acceptance of a standard radical colorectal cancer procedure;
• Complete perioperative data available;
• Adults with a pathologic diagnosis of colorectal cancer

You may not qualify if:

• Have or have had a previous history of other malignancies;
• Have a history of radiotherapy treatment;
• Have a history of inflammatory bowel disease;
• Have a familial history of genetic disorders;
• Missing baseline data (age, BMI, gender, previous medical history, etc.);
• Failed to leave the hospital earlier than medically indicated;
• Failed to sign an informed consent form.

Sponsors & Collaborators

• Dong Peng: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Colonic Neoplasms; Colorectal Neoplasms; Postoperative Complications

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 16, 2025
• First Posted: June 25, 2025
• Study Start: January 1, 2023
• Primary Completion: June 1, 2025
• Study Completion: September 1, 2025
• Last Updated: June 25, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)