Construction and Clinical Application of the Immune Map of Pancreatic Cancer Evolution

NCT07034339 | Recruiting

• 1 other identifier: IDPEPDAC
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

The intricate interplay between systemic immunity and tumors profoundly influences not only the onset and progression of tumors but also serves as a crucial window into understanding tumor evolution and treatment status. This project aims to establish a large, multi-center pancreatic cancer cohort and a standardized clinical sample repository, capturing multimodal immunity big data on pancreatic cancer occurrence, progression, and treatment response across the spatial dimension of "peripheral versus local" and the temporal dimension of "tumor evolution/pre- and post-treatment." By integrating patient imaging and clinical information, the investigators will develop a technical platform for intelligent extraction and fusion analysis of cross-scale, multimodal data, thereby mapping the immunity landscape of pancreatic cancer evolution, identifying characteristic changes in immunity parameters, and devising an AI model for early pancreatic cancer diagnosis with high accuracy and robust generalization capabilities, while also exploring the model's interpretability. Additionally, the investigators will focus on specific immune cell subsets associated with pancreatic cancer evolution and treatment response, elucidating their roles and mechanisms in the occurrence, development, and drug resistance of pancreatic cancer. This project will establish a high-quality, standardized, and shareable pancreatic cancer immunity sample and data repository, refine the framework for multi-dimensional immunity data fusion and analysis, and create a time-space atlas of local and systemic immunity in pancreatic cancer. This will facilitate a deeper understanding of the dynamics of systemic and local immunity in early-stage pancreatic cancer and at various stages of its evolution, offering novel insights and approaches for the diagnosis and treatment of pancreatic cancer.

Conditions

Immune Evasion, Tumor; Pancreas Cancer

Outcome Measures

Primary Outcomes (1)

• Pancreatic tumor resection

  Number of participants with pancreatic cancer

  3 years

Study Arms (3)

Conventional treatment queue

Dynamic follow-up queue

Neoadjuvant therapy queue

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants with pancreatic cancer, benign diseases, and healthy

You may qualify if:

• Healthy individuals without benign or malignant liver, gallbladder, and pancreas diseases
• Primary PDAC
• Patients with benign pancreatic tumors
• IPMN patients diagnosed by pathology/imaging

You may not qualify if:

• Having autoimmune diseases
• Accompanied by other malignant tumors
• History of tumor treatment (except thyroid cancer and breast cancer, cured for more than 5 years)
• Acute infection
• History of blood transfusion within the past 6 months, or use of drugs that affect peripheral blood components such as recombinant human erythropoietin and interleukin within 2 weeks
• Organ decompensation dysfunction
• Immunodeficiency syndrome
• Hematological precancerous lesions
• Accept immunosuppressive therapy
• Diagnosed coagulation disease

Sponsors & Collaborators

• First Affiliated Hospital of Zhejiang University: lead

Study Sites (1)

the First Affliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310003, China

RECRUITING

MeSH Terms

Conditions

Neoplasms; Pancreatic Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Central Study Contacts

Yangyang Wang

CONTACT

13957830918; 12418635@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 15, 2025
• First Posted: June 24, 2025
• Study Start: May 21, 2025
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: August 6, 2025

Record last verified: 2025-08

Locations

CN (1)