Conditions

Mild to Moderate Dementia

Outcome Measures

Primary Outcomes (4)

Change scores of Montreal Cognitive Assessment
The Montreal Cognitive Assessment (MoCA) will be used to assess general cognitive functions. It examines several cognitive domains with a total score of 30 and higher values indicate better cognitive functions. The MoCA has been shown to be a valid and promising tool to evaluate the global cognitive function in patients with stroke. Minimum: 0 (worst performance) Maximum: 30 (best performance) The psychometric properties of MoCA are good to excellent for patients with cerebrovascular diseases.
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .
Change scores of Stroop test
The participants will be tested under congruent and incongruent conditions. In the congruent condition, the participant will name the color ink of a word which is consistent with the written color name; whereas in the incongruent condition the participant will name the color ink differs from the written color name. The time to complete the task will be calculated for each condition.Minimum: 0 , Maximum: but typically no upper limit. Higher scores indicate worse performance (greater cognitive interference and slower response time).
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .
Change scores of Color trials test
For Part 1, the respondent uses a pencil to rapidly connect circles numbered 1-25 in sequence. For Part 2, the respondent rapidly connects numbered circles in sequence, but alternates between pink and yellow. The length of time to complete each trial is recorded, along with qualitative features of performance indicative of brain dysfunction, such as near-misses, prompts, number sequence errors, and color sequence errors.Minimum: Greater than 1 second (best performance) Maximum: No upper limit .Higher scores indicate worse performance (longer completion time and greater cognitive impairment).
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .
Change scores of Frontal Assessment Battery
This study utilizes this scale to assess various aspects of frontal lobe function, including executive function, behavioral regulation, and planning. The test consists of six subtests: Similarities, Verbal Fluency, Motor Sequencing, Conflicting Instructions, Go-No-Go, and Comprehending Behavior. Each subtest is scored from 0 to 3, with a total possible score of 18 points. The Taiwanese version of the frontal assessment scale has demonstrated good reliability and validity, showing consistency with tconsistency with the original version and strong construct validity. Minimum: 0 (worst performance) Maximum: 18 (best performance) Higher scores indicate better frontal lobe function, while lower scores suggest greater impairment.
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .

Secondary Outcomes (6)

Change scores of Barthel Index
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .
Change scores of Amsterdam Instrumental Activity of Daily Living,A-IADL
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .
Change scores of The Chinese Dementia-Quality of Life instrument, DQoL
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .
Change scores of The Cornell Scale for Depression in Dementia Chinese version
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .
Change scores of Clinical Dementia Rating, CDR
Before the intervention arms within a week, within a week after the waiting period ends, and within a week after the last treatment .

Study Arms (2)

VR training therapy

EXPERIMENTAL

Guide the patient through a 5-minute warm-up, which mainly involves explaining, familiarizing with, or reviewing VR operations. After the warm-up, proceed with the first part of the VR gardening training for 10 minutes, followed by 5 minutes of eye and stretching exercises. Then, continue with the second part of the VR gardening training for another 10 minutes, followed by 5 minutes of eye massage and stretching exercises. This sequence is repeated for a total of four cycles.

Device: VR-WLCDevice: CTL-VR

Waitlist control session

OTHER

During the waitlist period, patients will not receive any training but will receive regular phone calls to ensure equal attention.

Device: VR-WLCDevice: CTL-VR

Interventions

VR-WLCDevice

First, conduct the Virtual Reality (VR) training activity. After the evaluation is completed, proceed to the Waitlist Control (WLC) session, approximately 5 to 10 weeks later.

VR training therapyWaitlist control session

CTL-VRDevice

First, conduct the Control (CTL) session for approximately 5 to 10 weeks. After the evaluation is completed, proceed to the Virtual Reality (VR) training activity.

Eligibility Criteria

Age55 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Age over 55 years;
Diagnosed with mild or moderate dementia (primarily degenerative dementia) by a consulting physician or based on past medical records;

Sponsors & Collaborators

Chang Gung Memorial Hospital
Otherlead

Study Sites (1)

Tucheng Hospital, New Taipei City, commissioned and operated by Chang Gung Medical Foundation.

New Taipei City, Taiwan

RECRUITING

Ching-Yi Wu, ScDCONTACT+886-3-2118800 Ext. 5761 cywu@mail.cgu.edu.tw

Study Officials

Ching-yi Wu, ScD
Chang Gung Memorial Hospital
PRINCIPAL INVESTIGATOR

Central Study Contacts

Ching-yi Wu, ScD

CONTACT

#886-3-2118800 cywu@mail.cgu.edu.tw

The Feasibility and the Efficacy of the Full-immersive Virtual Reality Cognitive Training in Patients With Mild or Moderate Dementia

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (4)

Secondary Outcomes (6)

Study Arms (2)

VR training therapy

Waitlist control session

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (4)

Secondary Outcomes (6)

Study Arms (2)

VR training therapy

Waitlist control session

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations