The Effectiveness of Pulmonary Rehabilitation on Saturation in Patients With Idiopathic Pulmonary Fibrosis

NCT07031362 | Completed

• 1 other identifier: KKK333
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to evaluate the effects of a pulmonary rehabilitation (PR) program on health outcomes and the distance-saturation product in patients with IPF, by comparing two distinct groups: those who experience desaturation and those who do not during the six-minute walk test (6MWT).

Conditions

IPF; Pulmonary Fibrosis

Keywords

fibrosis; pulmonary rehabilitation; exercise training; saturation

Outcome Measures

Primary Outcomes (1)

• Exercise capacity

  Six minute walk test

  up to 8 weeks

Secondary Outcomes (5)

• Dyspnea Sensation

  Before and after the pulmonary rehabilitation programme (up to 8 weeks)

• Respiratory Functions

  Before and after the pulmonary rehabilitation programme (up to 8 weeks)

• Disease Related Quality of Life Measurement

  Before and after the pulmonary rehabilitation programme (up to 8 weeks)

• Health-Related Quality of Life Measurement

  Before and after the pulmonary rehabilitation programme (up to 8 weeks)

• Anxiety and Depression

  Before and after the pulmonary rehabilitation programme (up to 8 weeks)

Study Arms (2)

Desaturated Patients

ACTIVE COMPARATOR

Patients whose oxygen saturation dropped to 88% or below during the pre-rehabilitation 6MWT were classified as the desaturation group

Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Non-desaturated group

ACTIVE COMPARATOR

Those with oxygen saturation of 89% or above were classified as the non-desaturation group.

Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Interventions

EXERCISE TRAINING WITH OR WITHOUT MEDICATION OTHER

All patients who participated in the pulmonary rehabilitation and physiotherapy program underwent sessions lasting approximately two hours, conducted twice weekly over a period of eight weeks. The exercise program included breathing exercises, relaxation and stretching exercises, peripheral muscle strengthening exercises, and aerobic training.

Desaturated Patients; Non-desaturated group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of Idiopathic Pulmonary Fibrosis Patients who initiated antifibrotic therapy Patients who completed the pulmonary rehabilitation program.

You may not qualify if:

• Kardiovascular comorbid conditions

Sponsors & Collaborators

• Izmir Katip Celebi University: lead

MeSH Terms

Conditions

Pulmonary Fibrosis; Fibrosis

Interventions

Exercise; Dosage Forms

Condition Hierarchy (Ancestors)

Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Pharmaceutical Preparations; Technology, Pharmaceutical; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: June 3, 2025
• First Posted: June 22, 2025
• Study Start: January 1, 2013
• Primary Completion: October 30, 2019
• Study Completion: May 1, 2025
• Last Updated: June 22, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share