Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)

NCT07182955 | Recruiting

• 1 other identifier: 302240
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life. Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.

Conditions

MINOCA; Shortness of Breath; Atherosclerotic Heart Disease of Native Coronary Artery

Keywords

ANOCA/MINOCA; High Intensity Interval Training; CPET Phenotype; Cardiorespiratory Fitness

Outcome Measures

Primary Outcomes (1)

• Examine cardiorespiratory fitness (change in VO2max in mL/kg/min) with cardiopulmonary exercise testing (CPET) Phenotype.

  The investigators will assess VO2max (mL/kg/min) in 25 patients with ANOCA at the exercise laboratory.

  4 weeks

Secondary Outcomes (2)

• Assess Changes in cardio-respiratory fitness (CRF) (VO2max) with High-Intensity Interval Exercise Training (HIIT) in Patients with ANOCA.

  4 weeks

• Health Related Quality Of Life (HRQOL) questionnaire

  4 Weeks

Study Arms (1)

Exercise

EXPERIMENTAL

Remote 4 weeks of high-intensity interval exercise training on three non-consecutive days of the week.

Behavioral: EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Interventions

EXERCISE TRAINING WITH OR WITHOUT MEDICATION BEHAVIORAL

Remote 4 weeks of high-intensity interval exercise training on three non-consecutive days of the week.

Exercise

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18-85
• ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
• Able to use the wearable and participate in a remote exercise program
• Able to participate in intermittent high-intensity training.
• Able to perform cardiopulmonary exercise testing (CPET)
• Able to provide Health-related quality of life questionnaire (HRQOL)
• Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English

You may not qualify if:

• Systolic heart failure (LVEF \<50% or NYHA class III symptoms)
• Prior myocardial infarction, coronary revascularization
• Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment
• Pregnancy (due to unknown effects on CPET exercise markers)
• Inability to provide informed consent
• Life expectancy \<1 year
• Prisoners
• Cognitively impaired
• Non-English speaking

Sponsors & Collaborators

• University of Virginia: lead

Study Sites (1)

University of Virginia Health System

Charlottesville, Virginia, 22908, United States

RECRUITING

Related Publications (2)

• Angadi SS, Jarrett CL, Sherif M, Gaesser GA, Mookadam F. The effect of exercise training on biventricular myocardial strain in heart failure with preserved ejection fraction. ESC Heart Fail. 2017 Aug;4(3):356-359. doi: 10.1002/ehf2.12149. Epub 2017 Mar 16.

  PMID: 28772048 BACKGROUND

• Hambrecht R, Walther C, Mobius-Winkler S, Gielen S, Linke A, Conradi K, Erbs S, Kluge R, Kendziorra K, Sabri O, Sick P, Schuler G. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation. 2004 Mar 23;109(11):1371-8. doi: 10.1161/01.CIR.0000121360.31954.1F. Epub 2004 Mar 8.

  PMID: 15007010 BACKGROUND

MeSH Terms

Conditions

MINOCA; Dyspnea

Interventions

Exercise; Dosage Forms

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Pharmaceutical Preparations; Technology, Pharmaceutical; Investigative Techniques

Study Officials

• Jamieson M Bourque, MD, MHS

  University of Virginia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rahel Askari

CONTACT

434-243-7195; rahel.askari@uvahealth.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine & Radiology, Medical Director of Nuclear Cardiology and Stress Laboratory, Medical Director of Echocardiography

Study Record Dates

• First Submitted: July 11, 2025
• First Posted: September 19, 2025
• Study Start: August 11, 2025
• Primary Completion: March 30, 2026
• Study Completion: April 14, 2026
• Last Updated: September 19, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)