Long-term Effects of Lipoabdominoplasty on Pulmonary Function and Sleep Apnea Risk in Obese Subjects

NCT07029750 | Completed

• 1 other identifier: auhucgun05
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the long-term effects of lipoabdominoplasty on pulmonary function and obstructive sleep apnea (OSA) risk in obese patients. Participants were evaluated before and three months after surgery using spirometry, mMRC dyspnea scores, Epworth Sleepiness Scale (ESS), and STOP-Bang questionnaires.

Conditions

Obesity; Obstructive Sleep Apnea

Keywords

Obesity; Obstructive Sleep Apnea; Pulmonary Function; Lipoabdominoplasty

Outcome Measures

Primary Outcomes (7)

• Forced Vital Capacity (FVC)

  Forced Vital Capacity will be measured before six-minute walk test according to the guideline of ERS.

  8-10 minutes

• Forced Expiratory Volume in 1 second (FEV1)

  Forced Expiratory Volume in 1 second will be measured before six-minute walk test according to the guideline of ERS.

  8-10 minutes

• Peak Expiratory Flow (PEF)

  Peak Expiratory Flow will be measured before six-minute walk test according to the guideline of ERS.

  8-10 minutes

• Forced Expiratory Flow 25-75% (FEF25-75)

  Forced Expiratory Flow 25-75% will be measured before six-minute walk test according to the guideline of ERS.

  8-10 minutes

• mMRC Dyspnea Score

  The dyspnea score will be assessed with the mMRC dyspnea score and is based on five stages of dyspnea caused by exertion and is scored between 0-4.

  8-10 minutes

• Sleep Apnea Risk Score

  Sleep apnoea risk will be assessed using the Epworth Sleepiness Scale (ESS), a validated 8-item questionnaire that measures the subject's likelihood of falling asleep during daily activities. Higher scores reflect greater levels of daytime sleepiness and increased risk for conditions such as obstructive sleep apnoea.

  8-10 minutes

• Obstructive Sleep Apnea Risk Score

  Obstructive sleep apnoea risk will be assessed assessed using the STOP-Bang questionnaire, an eight-item screening tool that evaluates snoring, tiredness, observed apnoea, high blood pressure, BMI, age, neck circumference, and gender. A higher score indicates a greater risk of OSA, with a cut-off of ≥3 commonly used to identify high-risk individuals.

  8-10 minutes

Study Arms (1)

Participants

Obese subjects undergoing lipoabdominoplasty

Procedure: Lipoabdominoplasty

Interventions

Lipoabdominoplasty PROCEDURE

Combination of liposuction and abdominoplasty under general anesthesia. Klein solution used for tumescent liposuction. Muscle plication performed with 0 loop polydioxanone suture. Umbilicus preserved and repositioned. Postoperative compression corset used for 1 month.

Participants

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This prospective observational study will include adult patients (18-65 years) with a body mass index (BMI) over 30 kg/m² who are scheduled to undergo lipoabdominoplasty at a single tertiary care center. Eligible participants will be evaluated prior to surgery and again at 3 months postoperatively. Individuals with active pulmonary infections, chronic lung diseases, recent additional surgeries, or pregnancy will be excluded. All participants will provide written informed consent before enrollment. Approximately 24 participants are expected to complete both baseline and follow-up assessments.

You may qualify if:

• Age ≥ 18 years
• BMI ≥ 30 kg/m²
• Eligible for lipoabdominoplasty
• Voluntary informed consent

You may not qualify if:

• Pregnancy
• Active pulmonary infections or chronic lung disease
• Additional surgical interventions during study period
• Refusal to participate or incomplete data

Sponsors & Collaborators

• Atlas University: lead

Study Sites (1)

Istanbul Atlas University

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Obesity; Sleep Apnea, Obstructive

Interventions

Lipoabdominoplasty

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Abdominoplasty; Cosmetic Techniques; Therapeutics; Lipectomy; Bariatric Surgery; Bariatrics; Obesity Management; Surgical Procedures, Operative; Plastic Surgery Procedures

Study Officials

• Hikmet Ucgun, PT, PhD

  Atlas University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 12, 2025
• First Posted: June 19, 2025
• Study Start: July 1, 2022
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2024
• Last Updated: June 19, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)