Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle
CineP4
Evolution of Luteal Progesteronemia in a Modified Natural Cycle (Ovulation Triggered by hCG): Pilot Study
1 other identifier
interventional
40
0 countries
N/A
Brief Summary
This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels. The goal is to understand whether hCG affects the timing of the luteal phase and embryo implantation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2026
Longer than P75 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 11, 2025
CompletedFirst Posted
Study publicly available on registry
June 19, 2025
CompletedStudy Start
First participant enrolled
January 15, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 15, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 15, 2030
November 28, 2025
November 1, 2025
2.4 years
June 11, 2025
November 26, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Serum Progesterone Level on Day 3 After hCG Trigger
3 Days After hCG Injection
Study Arms (1)
1
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- At least 1 follicle of 17 mm or more
- Endometrium of 6 mm or more
- Plasma luteinizing hormone (LH) less than 2 times basal level (measured at the beginning of the cycle between D1 and D4) and progesteronemia less than 1.5 ng/mL
- For whom ovulation induction with recombinant hCG (Ovitrelle) is then proposed (standard care).
- care)
You may not qualify if:
- Patient whose venous capital contraindicates repeated blood sampling over a short period of time over a short period.
- Patient treated with exogenous natural progesterone (vaginal or injectable) which may interfere or synthetic progesterone, which may interfere with endogenous progesterone secretion.
- Patient who has not given written consent to participate in the study.
- Patient not fluent in French.
- Patient under guardianship, curators or without social security coverage.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Mizrachi Y, Horowitz E, Ganer Herman H, Farhi J, Raziel A, Weissman A. Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis. Hum Reprod Update. 2021 Jun 22;27(4):643-650. doi: 10.1093/humupd/dmab011.
PMID: 33829269BACKGROUNDLee VC, Li RH, Chai J, Yeung TW, Yeung WS, Ho PC, Ng EH. Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen-thawed embryo transfer in natural cycles. Fertil Steril. 2014 May;101(5):1288-93. doi: 10.1016/j.fertnstert.2014.01.040. Epub 2014 Mar 3.
PMID: 24602752BACKGROUND
Related Links
Study Officials
- PRINCIPAL INVESTIGATOR
Noémie RANISAVLJEVIC, Investigator Coordinator
CHU de Montpellier
Central Study Contacts
Noémie RANISAVLJEVIC, Senior Lecturer - Hospital Pra
CONTACT
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 11, 2025
First Posted
June 19, 2025
Study Start
January 15, 2026
Primary Completion (Estimated)
June 15, 2028
Study Completion (Estimated)
June 15, 2030
Last Updated
November 28, 2025
Record last verified: 2025-11
Data Sharing
- IPD Sharing
- Will not share